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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제6호
- 발행연도
- 2018.1
- 수록면
- 931 - 937 (7page)
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초록· 키워드
오류제보하기
Glycosyltransferases (GTs) from microbes are an emerging and rich source for efficient glycol-transformation of natural/unnatural compounds. Here, we probed the catalytic capability and substrate promiscuity of BmmGT1 from marine-derived Bacillus methylotrophicus B-9987. The regioselectivity of BmmGT1 on macrolactin A (1) was explored by optimization of the reaction conditions, in which a series of O-glycosylated macrolactins (1a-1e) were generated, including two new di/tri-O-glucosyl analogs (1b and 1e). Furthermore, BmmGT1 was able to catalyze the glycosylation of the thiol (S-) or amine (N-) sites of phenolic compounds (2 and 3), leading to the generation of N- (2a) or S-glycosides (3a and 3b). The present study demonstrates that BmmGT1 could serve as a potential enzyme tool for O-, N-, or S-glycosyl structural diversification of compounds for drug discovery.
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참고문헌 (16)
참고문헌 신청
Song MC / 2013 / Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes / Appl. Microbiol. Biotechnol. 97:5691~5704
Weymouth-Wilson AC / 1997 / The role of carbohydrates in biologically active natural products / Nat. Prod. Rep. 14:99~110
Vajaria BN / 2017 / Glycosylation: a hallmark of cancer? / Glycoconj. J. 34:147~156
Thibodeaux CJ / 2007 / Unusual sugar biosynthesis and natural product glycodiversification / Nature 446:1008~1016
Gantt RW / 2011 / Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules / Nat. Prod. Rep. 28:1811~1853
Weymouth-Wilson AC / 1997 / The role of carbohydrates in biologically active natural products / Nat. Prod. Rep. 14:99~110
Vajaria BN / 2017 / Glycosylation: a hallmark of cancer? / Glycoconj. J. 34:147~156
Thibodeaux CJ / 2007 / Unusual sugar biosynthesis and natural product glycodiversification / Nature 446:1008~1016
Gantt RW / 2011 / Enzymatic methods for glyco (diversification/randomization) of drugs and small molecules / Nat. Prod. Rep. 28:1811~1853
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