지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제8호
- 발행연도
- 2009.1
- 수록면
- 792 - 802 (11page)
이용수
초록· 키워드
오류제보하기
Antimicrobial peptides (AMPs) are considered to be a
promising alternative to conventional antibiotics for future
generations. We identified four novel hexapeptides with
antimicrobial activity: KCM11 (TWWRWW-NH2), KCM12
(KWRWIW-NH2), KCM21 (KWWWRW-NH2), and KRS22
(WRWFIH-NH2), through positional scanning of a synthetic
peptide combinatorial library (PS-SCL). The ability of
these peptides to inhibit the growth of a variety of bacteria
and unicellular fungi was evaluated. KCM11 and KRS22
preferentially inhibited the normal growth of fungal strains,
whereas KCM12 and KCM21 were more active against
bacterial strains. Bactericidal activity was addressed in a
clear zone assay against phytopathogenic bacteria, including
Pectobacterium spp., Xanthomonas spp., Pseudomonas
spp., etc. KCM21 showed the highest activity and was
effective against a wide range of target organisms. Application
of KCM21 with inoculation of Pectobacterium carotovorum
subsp. carotovorum on detached cabbage leaves resulted in
an immune phenotype or a significant reduction in symptom
development, depending on the peptide concentration.
Cytotoxicity of the four hexapeptides was evaluated in
mouse and human epithelial cell lines using an MTT test.
The results revealed a lack of cytotoxic effects.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Agrios, G. N. / 2005 / Plant Pathology / Academic Press
Bader, M. W. / 2005 / Recognition of antimicrobial peptides by a bacterial sensor kinase / Cell 122 : 461 ~ 472
Blondelle, S. E. / 1996 / Novel antimicrobial compounds identified using synthetic combinatorial library technology / Trends Biotechnol 14 : 60 ~ 65
Blondelle, S. E. / 1996 / Synthetic combinatorial libraries: Novel discovery strategy for identification of antimicrobial agents / Antimicrob. Agents Chemother 40 : 1067 ~ 10
Blondelle, S. E. / 2000 / Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relations
Bader, M. W. / 2005 / Recognition of antimicrobial peptides by a bacterial sensor kinase / Cell 122 : 461 ~ 472
Blondelle, S. E. / 1996 / Novel antimicrobial compounds identified using synthetic combinatorial library technology / Trends Biotechnol 14 : 60 ~ 65
Blondelle, S. E. / 1996 / Synthetic combinatorial libraries: Novel discovery strategy for identification of antimicrobial agents / Antimicrob. Agents Chemother 40 : 1067 ~ 10
Blondelle, S. E. / 2000 / Combinatorial libraries: A tool to design antimicrobial and antifungal peptide analogues having lytic specificities for structure-activity relations
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해양 생물 유래의 항균 펩타이드 및 작용 기작
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Diverse Antibacterial Activity of Pectobacterium carotovorum subsp. carotovorum Isolated in Korea
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Design and Engineering of Antimicrobial Peptides Based on LPcin- YK3, an Antimicrobial Peptide Derivative from Bovine Milk
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Pectobacterium carotovorum의 검출을 위한 PCR 진단법의 개발
미생물학회지
2009 .12
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First Report on Bacterial Soft Rot of Graft-cactus Chamaecereus silvestrii Caused by Pectobacterium carotovorum subsp. carotovorum in Korea
The Plant Pathology Journal
2007 .12
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혐기성 상태에서 암모니움 이온과 질산성 질소를 제거하는미생물의 분리 및 배양조건
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Solution Conformation of an Antimicrobial Peptide Gaegurin 4
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