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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제5호
- 발행연도
- 2011.1
- 수록면
- 525 - 528 (4page)
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초록· 키워드
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The Raf-1 kinase inhibitory protein (RKIP) can regulate multiple key signaling pathways. Specifically, RKIP binds to Raf-1 kinase and inhibits the Ras-Raf-1-MEK1/2-ERK1/2 pathway. Additionally, Raf-1 has been shown to translocate to mitochondria and thereby protect cells from stress-mediated apoptosis. Recently, HBx was found to stimulate the mitochondrial translocation of Raf-1, contributing to the anti-apoptotic effect. We found that RKIP was downregulated during HBx-mediated hepatocarcinogenesis.
In this study, we show that RKIP bound to Raf-1 and consequently inhibited the translocation of Raf-1 into mitochondria. This promoted the apoptosis of cells treated with apoptotic stimulus. Thus, the downregulation of RKIP increased the level of free Raf-1 and thereby elevated the mitochondrial translocation of Raf-1 during HBx-mediated hepatocarcinogenesis. The elevated Raf-1 mitochondrial translocation induced the increased anti-apoptotic effect and subsequently promoted HBx-mediated hepatocarcinogenesis.
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참고문헌 (15)
참고문헌 신청
Alexia, C / 2004 / An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signaling in hepatocarcinogenesis and in the resistance of the he
Chen, J / 2007 / Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress / J. Virol 81 : 6757 ~ 6760
Corbit, K. C / 2003 / Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein / J. Biol. Chem 278 : 13061 ~ 13068
Granovsky, A. E / 2008 / Raf kinase inhibitory protein: A signal transduction modulator and metastasis suppressor / Cell Res 18 : 452 ~ 457
Jeon, Y.-J / 2010 / Annexin A4 interacts with the NF-kappa B p50 subunit and modulates NF-kappa B transcriptional activity in a Ca2+-dependent manner / CELLULAR AND MOLECULA
Chen, J / 2007 / Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress / J. Virol 81 : 6757 ~ 6760
Corbit, K. C / 2003 / Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein / J. Biol. Chem 278 : 13061 ~ 13068
Granovsky, A. E / 2008 / Raf kinase inhibitory protein: A signal transduction modulator and metastasis suppressor / Cell Res 18 : 452 ~ 457
Jeon, Y.-J / 2010 / Annexin A4 interacts with the NF-kappa B p50 subunit and modulates NF-kappa B transcriptional activity in a Ca2+-dependent manner / CELLULAR AND MOLECULA
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