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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제4호
- 발행연도
- 2013.1
- 수록면
- 451 - 458 (8page)
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The human gastric pathogen Helicobacter pylori (Hp) has been considered a microaerophile. However, we recently reported that, when supplied with 10% CO2, Hp growth is stimulated by an atmospheric level of O2, suggesting that Hp is a capnophilic aerobe. In this study, we investigated the effects of aerobic O2 tension on Hp cells by comparing gene expression profiles of cultures grown under microaerobic and aerobic conditions in the presence of 10% CO2. The results showed that overall differences in gene expression in Hp cells grown under the two O2conditions were predominantly growth-phase-dependent.
At 6 h, numerous genes were down-regulated under the aerobic condition, accounting for our previous observation that Hp growth was retarded under this condition. At 36 h, however, diverse groups of genes involved in energy metabolism, cellular processes, transport, and cell envelope synthesis were highly up- or down-regulated under the aerobic condition, indicating a progression of the cultures from the log phase to the stationary phase. The expression of several oxidative stress-associated genes including tagD,katA, and rocF was induced in response to aerobic O2level, whereas trxA, trxB, and ahpC remained unchanged.
Altogether, these data demonstrate that aerobic O2 tension is not detrimental to Hp cells but stimulates Hp growth,supporting our previous finding that Hp may be an aerobic bacterium that requires a high CO2 level for its growth.
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참고문헌 (25)
참고문헌 신청
Boneca, I. G. / 2003 / A revised annotation and comparative analysis of Helicobacter pylori genomes / Nucleic Acids Res 31 : 1704 ~ 1714
Brown, L. M. / 2000 / Helicobacter pylori: Epidemiology and routes of transmission / Epidemiol. Rev 22 : 283 ~ 297
Bury-Mone, S. / 2006 / Helicobacter pylori a true microaerophile? / Helicobacter 11 : 296 ~ 303
Chalk, P. A. / 1994 / Metabolism of pyruvate and glucose by intact cells of Helicobacter pylori studied by 13C NMR spectroscopy / Microbiology 140 : 2085 ~ 2092
Chang, H. T. / 1995 / Kinetics of substrate oxidation by whole cells and cell membranes of Helicobacter pylori / FEMS Microbiol. Lett 129 : 33 ~ 38
Brown, L. M. / 2000 / Helicobacter pylori: Epidemiology and routes of transmission / Epidemiol. Rev 22 : 283 ~ 297
Bury-Mone, S. / 2006 / Helicobacter pylori a true microaerophile? / Helicobacter 11 : 296 ~ 303
Chalk, P. A. / 1994 / Metabolism of pyruvate and glucose by intact cells of Helicobacter pylori studied by 13C NMR spectroscopy / Microbiology 140 : 2085 ~ 2092
Chang, H. T. / 1995 / Kinetics of substrate oxidation by whole cells and cell membranes of Helicobacter pylori / FEMS Microbiol. Lett 129 : 33 ~ 38
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