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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제1호
- 발행연도
- 2018.1
- 수록면
- 12 - 21 (10page)
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초록· 키워드
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Photorhabdus temperata (PT), a gram-negative bacterium, lives symbiotically within entomopathogenic nematodes. The insecticidal compounds derived from Photorhabdus are used as biopesticides in agriculture. However, the physiological properties are not well characterized. In the course of our screening for neuroprotective and anti-neuroinflammatory substances from natural products, the culture broth of PT showed considerable activities. By activity-guided purification, five anthraquinones, namely, 3-methoxychrysazine (1), 1,3- dimethoxy-8-hydroxy-9,10-anthraquinone (2), 1,3,8-trihydroxy-9,10-anthraquinone (3), 3,8- dihydroxy-1-methoxy-9,10-anthraquinone (4), and 1,3,4-trimethoxy-8-hydroxy-9,10-anthraquinone (5), were isolated from the ethyl acetate fraction of the PT culture broth. Among the isolated compounds, 75 μM 3 significantly protected mouse hippocampal neuronal cells (HT22) against 5 mM glutamate-induced cell death via the inhibition of reactive oxygen species production, Ca2+ influx, and lipid peroxidation. Additionally, 3 and 4 effectively suppressed the interferon- γ-induced neuroinflammation of mouse-derived microglial cells (BV2) at 10 ng/ml, via the reduction of nitric oxide, interleukin-6, and tumor necrosis factor-α. Anthraquinones 3 and 4 derived from the PT culture broth are a potential starting point to discover neuroprotective and anti-neuroinflammatory drug leads. The novel compound 5 is reported for the first time in this study.
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참고문헌 (39)
참고문헌 신청
Monks TJ / 1992 / Quinone chemistry and toxicity / Toxicol. Appl. Pharmacol. 112:2~16
Bonadonna G / 1969 / Clinical evaluation of adriamycin, a new antitumour antibiotic / Br. Med. J. 3:503~506
Gessler NN / 2013 / Fungal anthraquinones (review) / Prikl. Biokhim. Mikrobiol. 49:109~123
Pankewitz F / 2007 / Anthraquinones as defensive compounds in eggs of Galerucini leaf beetles: biosynthesis by the beetles? / Arch. Insect. Biochem. Physiol. 66:98~108
van Gorkom BA / 2002 / Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1 / Br. J. Cancer 86:1494~1500
Bonadonna G / 1969 / Clinical evaluation of adriamycin, a new antitumour antibiotic / Br. Med. J. 3:503~506
Gessler NN / 2013 / Fungal anthraquinones (review) / Prikl. Biokhim. Mikrobiol. 49:109~123
Pankewitz F / 2007 / Anthraquinones as defensive compounds in eggs of Galerucini leaf beetles: biosynthesis by the beetles? / Arch. Insect. Biochem. Physiol. 66:98~108
van Gorkom BA / 2002 / Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1 / Br. J. Cancer 86:1494~1500
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