지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 583 - 590 (8page)
이용수
초록· 키워드
오류제보하기
Anticancer effect of methanol extract of Caesalpinia sappan L. on oral carcinoma (KB) and osteosarcoma (HOS) cells were investigated in this study. In order to elucidate the anticancer mechanism of Caesalpinia sappan L, we analyzed telomerase inhibitory effect of the methanol extract of Caesalpinia sappan L. In addition, we prepared 5 fraction samples according to its polarity differences and analyzed anticancer effects on oral carcinoma and osteosarcoma cells. Following results are obtained in this study.
1. 50% cell proliferation inhibitory value (IC50) of the methanol extract of Caesalpinia sappan L. against oral carcinoma (KB) cells and osteosarcoma (HOS) cells were 9.0 ㎍/㎖ and 10.9 ㎍/㎖, respectively.
2. The methanol extract of Caesalpinia sappan L. showed inhibitory effect of telomerase which is required for cancer cell immortality. Therefore, it seems that the anticancer effect of methanol extract of Caesalpinia sappan is at least partially due to telomerase inhibitory effect.
3. Five fraction samples were prepared according to its polarity and 88.7% of ingredient of total methanol extract was transferred to ethylacetate fraction. Thin layer chromatography analysis showed that dichloromethane fraction contained ingredient with relatively high polarity and ethylacetate fraction contained similar ingredient found in total methanol extract.
4. Anticancer effect was observed in n-hexane, dichloromethane, and ethylacetate fractions. The highest anticancer effect was found in dichloromethane fraction which had IC50 value of 4.4 ㎍/㎖ and > 4.0 ㎍/㎖ against oral carcinoma (KB) cells and osteosarcoma (HOS) cells, respectively.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
/ / 3-Benzylchroman derivatives related to brazilin from Sappan Lignum. Chem Pharm Bull 1986 (hara t) : 2506 ~ 2511
/ / Antiinflammatory principles of Caesalpinia sappan wood and of Haematoxylon campechianum wood. Planta Med 1977 hiki (h) : 214 ~ 220
/ / Augmentation of the cytotoxic effects of anticancer drugs by -ar-turmerone and extracts of the lithosperma and scutellaria roots against human leukemia cell lines. Yakhak
/ / Blackburn EH. Structure and function of telomeres. Nature 1991 : 569 ~ 573
/ / Brazilin protects cultured rat hepatocytes from BrCCl3-induced toxicity. Drug Chem Toxicol 1992 : 81 ~ 91
/ / Antiinflammatory principles of Caesalpinia sappan wood and of Haematoxylon campechianum wood. Planta Med 1977 hiki (h) : 214 ~ 220
/ / Augmentation of the cytotoxic effects of anticancer drugs by -ar-turmerone and extracts of the lithosperma and scutellaria roots against human leukemia cell lines. Yakhak
/ / Blackburn EH. Structure and function of telomeres. Nature 1991 : 569 ~ 573
/ / Brazilin protects cultured rat hepatocytes from BrCCl3-induced toxicity. Drug Chem Toxicol 1992 : 81 ~ 91
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
소목 추출물의 항균력 및 살균소독력
한국환경보건학회지
2011 .01
-
인체상피세포주와암세포주에대한소목추출물의증식억제효과
치위생과학회지
2007 .01
-
Anti-proliferative and Anti-telomerase Activity of Curcuma Rhizome Extract on Oral Squamous Cell Carcinoma and Osteosarcoma Cells
International Journal of Oral Biology
2007 .01
-
Protective effect of Caesalpinia sappan L.on hydrogen peroxide
대한동의병리학회 학술대회논문집
2003 .12
-
Protective Effect of Caesalpinia sappan L. on Hydrogen Peroxide
동의생리병리학회지
2003 .12
-
소목(蘇木) 물추출물의 G2/M기 정지를 통한 U937세포의 성장억제 효과
동의생리병리학회지
2010 .01
-
蘇木 물추출물의 G2/M기 정지를 통한 U937세포의 성장억제 효과
동의생리병리학회지
2010 .02
-
Effect of Ethyl Acetate Extract from Caesalpinia sappan L. on Melanogenesis in Melan-a cells
대한약학회 학술대회
2002 .01
-
소목 부탄올 추출물이 B16/F10 흑색종세포의 멜라닌 합성에 미치는 효과
약학회지
2002 .01
-
A DNA Strand-Nicking Principle of a Higher Plant, Caesalpinia sappan
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
A549 폐암세포주에 대한 蘇木 水抽出物의 세포고사 유도효과
동의생리병리학회지
2002 .06
-
천연 약용식물 추출물의 구강상피세포암 세포주에 대한 항암효과
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1999 .01
-
소목(蘇木)과 황련(黃連) 추출물(抽出物)의 Bacillus cereus와 Vibrio parahaemolyticus 에 대한 항세균활성(抗細菌活性)
대한본초학회지(본초분과학회지)
2010 .01
-
Comparison of antibacterial effects by the traditionally used medicinal herbal extracts, Caesalpinia Sappan and Paeonia suffruticosa
한국실험동물학회 학술발표대회 논문집
2008 .11
-
소목 추출물의 항산화 및 간보호작용
Environmental Analysis Health and Toxicology
2002 .09
-
소목(Caesalpinia sappan L.)의 에틸아세테이트 분획물이 Streptococcus mutans에 대한 항균활성 및 부착 억제
치위생과학회지
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0