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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
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Oral squamous cell carcinoma (OSCC) is the most frequent form of oral cancer and holds the eighth position in the cancer incidence ranking. OSCC patients are treated by classical therapeutic modalities consisting of surgery, radiotherapy, and/or chemotherapy. But OSCC still shows significant mortality rates. Thus, new therapeutic approaches have been investigated and the most promising one is naturally acquired agents with known anti-cancer effects. Genistein is a compound extracted from soy bean. Its anti-cancer effect on breast cancer is well established now and it is investigated whether it has similar effect on OSCC. It inhibited the growth and invasiveness of OSCC cells in vitro, but these effects did not work in living animals in vivo. Catechin is a compound from green tea and its anti-cancer effect on OSCC is known better than other agents. Catechin showed its anti-cancer effect in vitro via induction of apoptosis, cell cycle arrest, inhibition of growth, and down-regulation of invasion/metastasis. These effects were confirmed in vivo with mouse model. Cordycepin is one of major pharmacologically important components in Cordyceps Militaris and may exert its anti-cancer effect as an adenosine receptor agonist. In recent study, it inhibited the proliferation of OSCC cells via A3 adenosine receptor. But because there is very scarce evidence on this effect, more researches are needed on this theme.
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참고문헌 (24)
참고문헌 신청
Adlercreutz H / 1998 / Evolution, nutrition, intestinal microflora, and prevention of cancer: a hypothesis / Proc Soc Exp Biol Med 217 (3) : 241 ~ 246
Aggarwal BB / 2006 / Molecular targets of dietary agents for prevention and therapy of cancer / Biochem Pharmacol 71 (10) : 1397 ~ 1421
Akiyama T / 1987 / Genistein, a specific inhibitor of tyrosinespecific protein kinases / J Biol Chem 262 (12) : 5592 ~ 5595
Babich H / 2005 / Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity / Toxicol In Vitro 19 (2) : 231 ~
Banerjee S / 2005 / Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer / Can
Aggarwal BB / 2006 / Molecular targets of dietary agents for prevention and therapy of cancer / Biochem Pharmacol 71 (10) : 1397 ~ 1421
Akiyama T / 1987 / Genistein, a specific inhibitor of tyrosinespecific protein kinases / J Biol Chem 262 (12) : 5592 ~ 5595
Babich H / 2005 / Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity / Toxicol In Vitro 19 (2) : 231 ~
Banerjee S / 2005 / Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer / Can
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