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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한구강악안면외과학회 대한구강악안면외과학회지 대한구강악안면외과학회지 제34권 제3호
발행연도
2008.1
수록면
250 - 265 (16page)

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초록· 키워드

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Distraction osteogenesis is a well-established clinical treatment for limb length discrepancy and skeletal deformities. Appropriate mechanical tension- stress is believed not to break the callus but rather to stimulate osteogenesis. In contrast to fracture healing, the mode of bone formation in distraction osteogenesis is primarily intramembranous ossification. Although the biomechanical, histological, and ultrastructural changes associated with distraction osteogenesis have been widely described, the basic biology of the process is still not well known. Moreover, the molecular mechanisms in distraction osteogenesis remain largely unclear. Recent studies have implicated the growth factor cascade is likely to play an important role in distraction. And current reserch suggested that mechanical tension-stress modulates cell shape and phenotype, and stimulates the expression of the mRNA for bone matrix proteins. The purpose of this study is to examine the pattern of expression of growth factors(TGF-β1, IGF-I, bFGF) and extracellular matrix proteins(osteoclacin, osteonectin) related to osteogenesis by osteodistraction of the mandible in rabbits. 24 rabbits is used for this experiment. Experimental group are gradual distraction(0.7mm, twice/day), acute distraction(1.4mm, twice/day) and control group is only osteotomized. After 5 days latency, osteotomic site is distracted for each 7 days and 3.5 days. Consolidation period is 28 days. The animal is sacrificed at the 3th, 7th, 14th, 28th. The distracted bone is examined by immunohistochemical analysis and RT-PCR analysis. The results obtained from this study were as follow : No significant difference was found on clinical examination according to distraction rate, but gradual distraction was shown to improve regenerate bone formation on radiographic and histologic examination. Growth factors and extracelluar matrix proteins expression increased in distraction group than control group. From these results, it could be stated that graudal distraction is shown to improve and accelerate bone formation and mechanical stress like distraction has considerable effects on osteogenesis related factors. And rabbit is the most appropriate animal model for further reseach on the molecular mechanisms that mediate osteodistraction. It is believed that understanding the biomolecular mechanisms that mediate distraction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone healing.
#Distraction osteogenesis #Molecular mechanisms #Growth factors #Extracellular matrix proteins

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참고문헌 (29)

참고문헌 신청
[학술지 google schola Codivilla A / 1905 / On the means of lengthening in the lower limb, the muscles and tissues which are shortened through deformity / Am J Orthop Surg 2 : 353 ~ 369 google schola Eingartner C / 1999 / Growth factors in distraction osteogenesis. Immunohistological pattern of TGF-beta 1, IGF-I in human callus induced by distraction osteogenesis / Int O google schola Ilizarov GA / 1954 / A new principle of osteosynthesis with the use of crossing pins and rings. In Collection of Scientific Works of the Kurgan Regional Scientific Medical Society / Kurg google schola Ilizarov GA / 1989 / The tension-stress effect on the genesis and growth of tissues: I. The influence of stability of fixation and soft-tissue preservation / Clin Orthop 238 google schola

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