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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 274 - 282 (9page)
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초록· 키워드
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Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first detected during pregnancy. It can result in pregnancy complications such as birth injury, stillbirth. Fatty acid-binding protein 4 (FABP4), found in adipose tissue, is associated with insulin resistance, and type 2 diabetes. The aim of this study was to investigate whether FABP4 in the placenta and decidua of pregnant women with GDM is higher than that in normal pregnant women, and whether serum from pregnant women with GDM may cause adipocytes to secrete more FABP4 than does serum from a normal pregnant group.
Methods: We obtained placentas, deciduas, and serum from 12 pregnant women with GDM and 12 normal pregnant women and performed enzyme-linked immunosorbent assay, real time quantitative-polymerase chain reaction. We cultured human pre-adipocytes for 17 days with GDM and non-GDM serum and performed western blot, real time quantitative-polymerase chain reaction, and oil red O staining.
Results: Expression of FABP4 in serum, placenta and decidua of pregnant women with GDM was significantly higher than that in normal pregnant women. Serum from pregnant women with GDM increased the expression of FABP4 mRNA and decreased the expression of adiponectin mRNA in human pre-adipocytes significantly. Adipocyte cultured in GDM serum showed significantly greater lipid accumulation than those cultured in normal serum.
Conclusion: Our results suggest that FABP4 is higher in placenta and decidua from pregnant women with GDM. Increased circulating FABP4 in maternal serum from pregnant women with GDM may originate from adipocytes and the placenta. Circulating FABP4 can induce increased insulin resistance and decreased insulin sensitivity.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Baz B / 2016 / Endocrinology of pregnancy:gestational diabetes mellitus. Definition, aetiological and clinical aspects / Eur J Endocrinol 174 : R43 ~ R51
Buchanan TA / 1990 / Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild
Buchanan TA / 2005 / Gestational diabetes mellitus / J Clin Invest 115 : 485 ~ 491
Catalano PM / 2006 / Adiponectin in human pregnancy:implications for regulation of glucose and lipid metabolism / Diabetologia 49 : 1677 ~ 1685
Desoye G / 2007 / The human placenta in gestational diabetes mellitus: the insulin and cytokine network / Diabetes Care 30 (2) : S120 ~ S126
Buchanan TA / 1990 / Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild
Buchanan TA / 2005 / Gestational diabetes mellitus / J Clin Invest 115 : 485 ~ 491
Catalano PM / 2006 / Adiponectin in human pregnancy:implications for regulation of glucose and lipid metabolism / Diabetologia 49 : 1677 ~ 1685
Desoye G / 2007 / The human placenta in gestational diabetes mellitus: the insulin and cytokine network / Diabetes Care 30 (2) : S120 ~ S126
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