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ObjectiveEndometriosis, a common hormone-dependent chronic inflammatory disease causes various symptoms includingpelvic pain, which affect the physical and psychological quality of life in women of reproductive age. The presentstudy aimed to assess the quality of life of Iranian women with endometriosis using the World Health OrganizationQuality of Life Instrument, Short Form (WHOQOL-BREF) questionnaire. MethodsThis cross-sectional study performed in Tehran between October 2014 and July 2016 included 70 Iranian women withendometriosis. The Iranian version of the WHOQOL-BREF questionnaire was used to measure quality of life in thesewomen. The Pearson's correlation coefficient, the paired and the independent t-tests, and a linear regression modelwere used to statistically analyze the data using the SPSS software version 16.0. ResultsThe total mean score of the WHOQOL-BREF questionnaire was 80.58. The highest and the lowest mean scoreswere observed in the environmental (28.15) and the physical health domains (10.59), respectively. A multiple linearregression model (backward method) showed that insurance coverage was associated with the total WHOQOL-BREFscore, whereas age, insurance coverage, and income level were associated with domains 1 through 4, respectively(P<0.05). ConclusionEndometriosis affects various aspects of the quality of life of Iranian women who therefore require holisticmanagement focused on both, the physical and psychological aspects of treatment.

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