지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 565 - 574 (10page)
이용수
초록· 키워드
오류제보하기
ObjectiveThis study aimed to investigate the association between preterm birth and epigenetic mechanisms in the amnion. MethodsWe examined the association between differentially methylated regions (DMRs) and differentially expressed genes(DEG) using a cytosine-phosphate-guanine methylation array and whole-transcriptome sequencing from the amnion(preterm birth, n=5; full term, n=5). We enrolled 35 participants for mRNA expression analysis and pyrosequencing:16 full-term and 19 preterm subjects. We compared the association of integrin subunit alpha 11 (ITGA11) andthrombospondin 2 (THBS2) gene methylation status with mRNA expression in the amnion. ResultsIn the preterm birth group, methylation of ITGA11 and THBS2 genes was significantly lower (ITGA11 gene: 60.30%vs. 73.16%, P<0.05; THBS2 gene: 64.59% vs. 73.16%, P<0.05), and the expression of the genes was significantly higherthan that in the full-term group (ITGA11 gene: 14.20 vs. 1.57, P<0.01; THBS2 gene: 1.18 vs. 10.34, P<0.05). ConclusionMethylation of the ITGA11 and THBS2 genes in the amnion was associated with preterm birth. Thus, ITGA11 andTHBS2 gene methylation status in the amnion may be valuable in explaining the mechanism underlying preterm birth.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Arzuaga BH / 2011 / Limits of human viability in the United States: a medicolegal review / Pediatrics 128:1047~1052
Parets SE / 2014 / Preterm birth and its long-term effects: methylation to mechanisms / Biology (Basel) 3:498~513
Jae Won Lim / 2011 / The changing trends in live birth statistics in Korea, 1970 to 2010 / Korean Journal of Pediatrics 54(11):429~435
Bhutta AT / 2002 / Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis / JAMA 288:728~737
황한성 / 2015 / Practice patterns in the management of threatened preterm labor in Korea: A multicenter retrospective study / Obstetrics & Gynecology Science 58(3):203~209
Parets SE / 2014 / Preterm birth and its long-term effects: methylation to mechanisms / Biology (Basel) 3:498~513
Jae Won Lim / 2011 / The changing trends in live birth statistics in Korea, 1970 to 2010 / Korean Journal of Pediatrics 54(11):429~435
Bhutta AT / 2002 / Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis / JAMA 288:728~737
황한성 / 2015 / Practice patterns in the management of threatened preterm labor in Korea: A multicenter retrospective study / Obstetrics & Gynecology Science 58(3):203~209
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