지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 8 - 14 (7page)
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Objective To assess the diagnostic accuracy of random urine protein-creatinine (P/C) ratio for prediction of significant proteinuria in preeclampsia as an alternative to the time-consuming 24-hour urine protein collection.
Methods Retrospective record analysis was performed on 140 pregnant women who were admitted with suspicion for preeclampsia from January 2006 to June 2011. Random urine protein and/or 24-hour urine protein levels were assessed and their correlation to random urine P/C ratio and 24-hour urine protein excretion was evaluated.
Results Out of 140 patients, random urine P/C ratio or/and 24-hour urine protein was performed in 79 patients to evaluate significant proteinuria. Of 79 patients, 46 (58%) underwent both tests whereas in 33 women (42%) 24-hour urine collection was not available due to urgent delivery. In 39 cases (85%), significant proteinuria (≥300 mg/24 hr) was detected with 6 cases (13%) having values over 5,000 mg/24 hr, corresponding to the diagnosis of severe preeclampsia. Random urine P/C ratio highly correlated with 24-hour urine protein excretion (r=0.823, P<0.01). The optimal random urine P/C ratio cutoff points were 0.63 and 4.68 for 300 mg/24 hr and 5,000 mg/24 hr of protein excretion, respectively. with each sensitivity, specificity, and positive and negative predictive values of 87.1%, 100%, 100%, and 58.3%; and 100%, 85%, 50%, and 100%, for significant and severe preeclampsia, respectively.
Conclusion Random urine P/C ratio is a reliable indicator of significant proteinuria in preeclampsia and may be better at providing earlier diagnostic information than the 24-hour urine protein excretion with more accuracy than the urinary dipstick test.
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참고문헌 (23)
참고문헌 신청
ACOG Committee on Obstetric Practice / 2002 / ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002 / Int J Gynaecol Obstet
Bell SC / 1999 / The role of observer error in antenatal dipstick proteinuria analysis / Br J Obstet Gynaecol 106 : 1177 ~ 1180
Brown MA / 2001 / The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Preg
Chitalia VC / 2001 / Cost-benefit analysis and prediction of 24-hour proteinuria from the spot urine protein-creatinine ratio / Clin Nephrol 55 : 436 ~ 447
Christopher-Stine L / 2004 / Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis / J Rheumatol 31 : 1557 ~ 1559
Bell SC / 1999 / The role of observer error in antenatal dipstick proteinuria analysis / Br J Obstet Gynaecol 106 : 1177 ~ 1180
Brown MA / 2001 / The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Preg
Chitalia VC / 2001 / Cost-benefit analysis and prediction of 24-hour proteinuria from the spot urine protein-creatinine ratio / Clin Nephrol 55 : 436 ~ 447
Christopher-Stine L / 2004 / Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis / J Rheumatol 31 : 1557 ~ 1559
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