지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 421 - 424 (4page)
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초록· 키워드
오류제보하기
Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Althoughperipheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity israrely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), asurfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-yearoldwoman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrELfree,polymeric micelle formulation of paclitaxel. One week after her fourth round of chemotherapy, she experienceda transient episode of aphasia for 45 minutes. Electroencephalography demonstrated epileptiform discharges. To ourknowledge, this is the first reported case of seizure associated with a CrEL-free formulation of paclitaxel. Althoughrare, patients and clinicians should remain aware of the risk of non-convulsive seizure following infusion of thispaclitaxel formulation.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Magge RS / 2015 / The double-edged sword: neurotoxicity of chemotherapy / Blood Rev 29:93~100
Gelderblom H / 2001 / Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation / Eur J Cancer 37:1590~1598
Deepa G / 2012 / Polymer nanoparticles--a novel strategy for administration of Paclitaxel in cancer chemotherapy / Curr Med Chem 19:6207~6213
Illan-Gala I / 2015 / Nonconvulsive status epilepticus secondary to paclitaxel administration / Epilepsy Behav Case Rep 4:20~22
O'Connor TL / 2009 / Delayed seizure associated with paclitaxel-Cremophor el in a patient with early-stage breast cancer / Pharmacotherapy 29:993~996
Gelderblom H / 2001 / Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation / Eur J Cancer 37:1590~1598
Deepa G / 2012 / Polymer nanoparticles--a novel strategy for administration of Paclitaxel in cancer chemotherapy / Curr Med Chem 19:6207~6213
Illan-Gala I / 2015 / Nonconvulsive status epilepticus secondary to paclitaxel administration / Epilepsy Behav Case Rep 4:20~22
O'Connor TL / 2009 / Delayed seizure associated with paclitaxel-Cremophor el in a patient with early-stage breast cancer / Pharmacotherapy 29:993~996
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