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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 337 - 343 (7page)
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ObjectiveThe objective of this study was to determine the optimal cutoff level of serum squamous cell carcinoma antigen (SCCAg)to detect recurrent cervical squamous cell carcinoma during post-treatment surveillance. MethodsBetween January 2000 and July 2014, a total of 158 women with cervical squamous cell carcinoma were treatedwith radiotherapy with or without concurrent chemotherapy at our department. A total of 1,550 serum SCC-Ag testsperformed during post-treatment surveillance of the 158 patients were included in this retrospective study. ResultsDuring post-treatment surveillance, 53 patients were diagnosed as having recurrent cervical cancer based on biopsyor a radiological test showing progression of a lesion. Receiver operating characteristic (ROC) curve for serum SCC-Agto diagnose recurrent cervical squamous cell carcinoma showed that the area under the ROC curve was 0.914 (95%confidence interval, 0.887–0.942; P<0.001). The best cutoff value for serum SCC-Ag to obtain the highest Youden'sindex was ≥2 ng/mL (sensitivity, 80.2%; specificity, 94.6%). ConclusionSerum SCC-Ag test was helpful in detecting recurrent cervical squamous cell carcinoma during post-treatmentsurveillance, and the optimal cutoff value was ≥2 ng/mL. The researchers recommend active imaging studies, whenserum SCC-Ag level ≥2 ng/mL during post-treatment surveillance.
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참고문헌 (29)
참고문헌 신청
2016 / Practice bulletin no. 157: cervical cancer screening and prevention / Obstet Gynecol 127:e1~e20
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Salani R / 2011 / Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncologists recommendations / Am J Obstet Gynecol 204:466~478
Zanagnolo V / 2009 / Surveillance procedures for patients with cervical carcinoma: a review of the literature / Int J Gynecol Cancer 19:194~201
Duk JM / 1989 / Elevated levels of squamous cell carcinoma antigen in patients with a benign disease of the skin / Cancer 64:1652~1656
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Salani R / 2011 / Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncologists recommendations / Am J Obstet Gynecol 204:466~478
Zanagnolo V / 2009 / Surveillance procedures for patients with cervical carcinoma: a review of the literature / Int J Gynecol Cancer 19:194~201
Duk JM / 1989 / Elevated levels of squamous cell carcinoma antigen in patients with a benign disease of the skin / Cancer 64:1652~1656
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