지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 249 - 259 (11page)
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The decrease in maternal plasma total (free + albumin-bound) tryptophan (Trp) during the third pregnancy trimester is attributed to induction of indoleamine 2,3-dioxygenase (IDO). When measured, free [Trp] is increased because of albumin depletion and non-esterified fatty acid elevation. The Trp depletion concept in pregnancy is therefore not supported because of incorrect interpretation of changes in Trp disposition and also for not addressing mouse strain differences in Trp-related responses and potential inhibition of Trp transport by the IDO inhibitor 1-methyl tryptophan. Application of the Trp utilization concept in pregnancy offers several physiological advantages favoring fetal development and successful outcome, namely provision of Trp for fetal protein synthesis and growth, serotonin for signaling pathways, kynurenic acid for neuroprotection, quinolinic acid for NAD+ synthesis, and other kynurenines for suppression of T cell responses. An excessive increase in Trp availability could compromise pregnancy by undermining T cell suppression, e.g., in pre-eclampsia.
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참고문헌 (24)
참고문헌 신청
Abou-Saleh MT / 1998 / Postpartum mood changes and plasma amino-acids / Curr Psychiatry 5 : 314 ~ 319
Badawy AA / 1976 / Animal liver tryptophan pyrrolases:absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity / Biochem J 158 :
Badawy AA / 1988 / Effects of pregnancy on tryptophan metabolism and disposition in the rat / Biochem J 255 : 369 ~ 372
Badawy AA / 2002 / Tryptophan metabolism in alcoholism / Nutr Res Rev 15 : 123 ~ 152
Badawy AA / 2010 / Plasma free tryptophan revisited: what you need to know and do before measuring it / J Psychopharmacol 24 : 809 ~ 815
Badawy AA / 1976 / Animal liver tryptophan pyrrolases:absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity / Biochem J 158 :
Badawy AA / 1988 / Effects of pregnancy on tryptophan metabolism and disposition in the rat / Biochem J 255 : 369 ~ 372
Badawy AA / 2002 / Tryptophan metabolism in alcoholism / Nutr Res Rev 15 : 123 ~ 152
Badawy AA / 2010 / Plasma free tryptophan revisited: what you need to know and do before measuring it / J Psychopharmacol 24 : 809 ~ 815
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