지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 6 - 10 (5page)
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초록· 키워드
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Background/Aims: Photodynamic therapy (PDT) has a promising effect on nonresectable cholangiocarcinoma (CC) but its long term data is not yet available. This study examined the long term outcome and factors associated with increased survival after performing PDT for hilar cholangiocarcinoma.
Methods: A list of 393 patients with a diagnosis of hilar CC was retrieved from the database of Soonchunhyang University Hospital (Seoul, Korea) and these patients were seen from January 1, 2001, to April 1, 2010. We retrospectively reviewed the records of 74 patients who underwent PDT in addition to biliary stenting with/without chemoradiation.
Results: The median overall survival from the date of diagnosis to death or to the last follow-up was 11.7 months (range: 2.2∼78.4). After performing PDT, a complete remission was observed in 1.3% (1/74) of the patients who had a superficial depth of tumor without lymph node involvement. On multivariate analysis using the Cox regression model, increasing the time to treatment after the diagnosis was a statistically significant predictor of shorter survival after PDT [Odds ratio: 3.25, 95% confidence interval (CI): 1.90∼4.71, p=0.034].
Conclusions: Although PDT does not prevent progression of CC, it appears to control the cholestasis. The early treatment of PDT after the diagnosis showed a survival benefit for patients with advanced hilar CC.
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참고문헌 (19)
참고문헌 신청
Berr F / 2000 / Photodynamic therapy for advanced bile duct cancer: evidence for improved palliation and extended survival / Hepatology 31 : 291 ~ 298
Bismuth H / 1975 / Intrahepatic cholangioenteric anastomosis in carcinoma of the hilus of the liver / Surg Gynecol Obstet 140 : 170 ~ 178
Bowling TE / 1996 / A retrospective comparison of endoscopic stenting alone with stenting and radiotherapy in non-resectable cholangiocarcinoma / Gut 39 : 852 ~ 855
Burke EC / 1998 / Hilar Cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system / Ann Su
Cheon YK / 2007 / Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy / AMERICAN JOURNAL
Bismuth H / 1975 / Intrahepatic cholangioenteric anastomosis in carcinoma of the hilus of the liver / Surg Gynecol Obstet 140 : 170 ~ 178
Bowling TE / 1996 / A retrospective comparison of endoscopic stenting alone with stenting and radiotherapy in non-resectable cholangiocarcinoma / Gut 39 : 852 ~ 855
Burke EC / 1998 / Hilar Cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system / Ann Su
Cheon YK / 2007 / Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy / AMERICAN JOURNAL
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