지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 302 - 308 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Dry eye syndrome is commonly thought of as an inflammatory disease, and we have previously presenteddata showing the effectiveness of topical TNF-α blocker agents for the treatment of this condition. Thepurpose of this study was to investigate the effectiveness of the TNF-α blocking agent HL036337 comparedto cyclosporine A for the treatment of dry eye induced inflammation in order to establish whether HL036337represents a more effective method for suppressing inflammation. The efficacy of HL036337 and cyclosporineA was determined using an experimental murine dry eye model.
Methods: The TNF-α blocker HL036337 is a modified form of TNF receptor I. Using dry eye induced C57BL/6mice (n = 45), corneal erosion was measured at day 4 and 7 after topical treatment with cyclosporine A orHL036337. To determine the effective treatment dose, 0.25, 0.5, 1, 2.5, and 5 mg/mL of HL036337 were topicallyadministered twice per day to dry eye induced murine corneas for 1 week.
Results: The optimal concentration of the TNF-α blocker HL036337 for treatment of dry eye induced cornealerosion was determined to be 1 mg/mL. Dry eye induced corneal erosion was improved after 1 week with topicallyapplied cyclosporine A and HL036337 at 1 mg/mL.
Conclusions: HL036337 administered topically at 1 mg/mL effectively improved corneal erosion induced by dryeye. This finding may also suggest that inhibition of TNF-α can improve dry eye syndrome.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Uchino M / 2008 / Prevalence of dry eye disease among Japanese visual display terminal users / Ophthalmology 115:1982~1988
Guo B / 2010 / Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study / Ophthalmic Epidemiol 17:234~241
김웅재 / 2007 / 설문조사에 의한 국내 건성안 환자의 진단 및 치료 현황 / 대한안과학회지 48(12):1614~1622
Schiffman RM / 2003 / Utility assessment among patients with dry eye disease / Ophthalmology 110:1412~1419
Buchholz P / 2006 / Utility assessment to measure the impact of dry eye disease / Ocul Surf 4:155~161
Guo B / 2010 / Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study / Ophthalmic Epidemiol 17:234~241
김웅재 / 2007 / 설문조사에 의한 국내 건성안 환자의 진단 및 치료 현황 / 대한안과학회지 48(12):1614~1622
Schiffman RM / 2003 / Utility assessment among patients with dry eye disease / Ophthalmology 110:1412~1419
Buchholz P / 2006 / Utility assessment to measure the impact of dry eye disease / Ocul Surf 4:155~161
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