지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 369 - 374 (6page)
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초록· 키워드
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Purpose: To assess the effectiveness and tolerability of cyclosporine ophthalmic emulsion (CsA) 0.05% in patients with moderate to severe dry eye disease in Korea.
Methods: This was a prospective, multicenter, open-label, surveillance study of 392 Korean patients with moderate to severe dry eye disease who were treated with CsA 0.05% for three months. An assessment of effectiveness was performed at baseline, and after 1, 2, and 3 months. The primary effectiveness outcomes were changes in ocular symptoms and Schirmer score. The secondary effectiveness outcomes were a change in conjunctival staining, use of artificial tears, global evaluation of treatment, and patient satisfaction. The primary safety outcome was the incidence and nature of adverse events.
Results: A total of 362 patients completed the study. After three months, all ocular symptom scores were significantly reduced compared to the baseline values, while the Schirmer scores were significantly increased relative to baseline (p < 0.0001). After three months, there were significant reductions from baseline in conjunctival staining (p < 0.01) and use of artificial tears (p < 0.0001). According to clinicians’ global evaluations, most patients (>50%) experienced at least a 25% to 50% improvement in symptoms from baseline at each follow-up visit.
The majority of patients (72.0%) were satisfied with the treatment results, and 57.2% reported having no or mild symptoms after treatment. The most common adverse events were ocular pain (11.0%).
Conclusions: Our findings indicate that CsA 0.05% is an effective and tolerable treatment for dry eye disease in Korean clinical practice.
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참고문헌 (25)
참고문헌 신청
/ 2007 / Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop / Ocul Surf 2007 (5) : 163 ~ 178
/ 2007 / The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop / Ocul Surf 200
/ 2007 / The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop / Ocul Surf 2007 (5) : 93 ~ 107
Doughty MJ / 1997 / A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada / Optom Vi
Doughty MJ / 2009 / Efficacy of different dry eye treatments with artificial tears or ocular lubricants:a systematic review / Ophthalmic Physiol Opt 29 : 573 ~ 583
/ 2007 / The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop / Ocul Surf 200
/ 2007 / The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop / Ocul Surf 2007 (5) : 93 ~ 107
Doughty MJ / 1997 / A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada / Optom Vi
Doughty MJ / 2009 / Efficacy of different dry eye treatments with artificial tears or ocular lubricants:a systematic review / Ophthalmic Physiol Opt 29 : 573 ~ 583
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