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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 86 - 91 (6page)
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Purpose: The purpose of the study was to differentiate ischemic central retinal vein occlusion (CRVO) from nonischemic CRVO during the early acute phase using plasma homocysteine as a biochemical marker.
Methods: Fasting plasma homocysteine, serum vitamin B12, and folate levels were measured in 108 consecutive unilateral elderly adult (age >50 years) ischemic CRVO patients in the absence of local and systemic disease and compared with a total of 144 age and sex matched nonischemic CRVO patients and 120 age and sex matched healthy control subjects.
Results: Homocysteine level was significantly increased in the patients with ischemic CRVO in comparison with nonischemic CRVO patients (p = 0.009) and also in comparison with control subjects (p < 0.001). Analysis also showed that hyperhomocysteinemia was associated with increased incidence of ischemic CRVO (odds ratio, 18) than that for nonischemic CRVO (odds ratio, 4.5). Serum vitamin B12 and folate levels were significantly lower (p < 0.001) in CRVO patients compared to the control but were not significantly different between nonischemic and ischemic CRVO patients (p > 0.1).
Conclusions: Hyperhomocysteinemia can be regarded as useful in differentiating nonischemic and ischemic CRVO during the early acute phase in absence of local and systemic disease in the elderly adult (age >50 years) population.
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참고문헌 (23)
참고문헌 신청
Cahill MT / 2003 / Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive di
Chua B / 2005 / Homocysteine and retinal vein occlusion: a population-based study / Am J Ophthalmol 139 : 181 ~ 182
Chua B / 2006 / Homocysteine and retinal emboli: the Blue Mountains Eye Study / Am J Ophthalmol 142 : 322 ~ 324
Cugati S / 2007 / Retinal vein occlusion and vascular mortality: pooled data analysis of 2 population-based cohorts / Ophthalmology 114 : 520 ~ 524
Finkelstein JD / 2006 / Inborn errors of sulfur-containing amino acid metabolism / J Nutr 136 (6) : 1750 ~ 1754
Chua B / 2005 / Homocysteine and retinal vein occlusion: a population-based study / Am J Ophthalmol 139 : 181 ~ 182
Chua B / 2006 / Homocysteine and retinal emboli: the Blue Mountains Eye Study / Am J Ophthalmol 142 : 322 ~ 324
Cugati S / 2007 / Retinal vein occlusion and vascular mortality: pooled data analysis of 2 population-based cohorts / Ophthalmology 114 : 520 ~ 524
Finkelstein JD / 2006 / Inborn errors of sulfur-containing amino acid metabolism / J Nutr 136 (6) : 1750 ~ 1754
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