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자료유형
학술저널
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저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제30권 제5호
발행연도
2016.1
수록면
319 - 325 (7page)

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Purpose: To describe the change of lacrimal gland volumes in Korean patients with thyroid-associated ophthalmopathy(TAO) via computed tomography (CT). Methods: A retrospective review of CT images from 217 TAO patients and 135 control subjects was performed. The TAO patients were diagnosed between May 2005 and May 2014 and had a CT performed on initial presentation(330 orbital CT scans). These images were compared with 270 orbital CT scans from the controlgroup, obtained between May 2013 and May 2014. An open source DICOM viewer was used to calculate thevolume of the lacrimal gland. Results: The mean volume of the lacrimal gland in TAO patients was 0.816 cm3 in the right orbit (standard deviation[SD], 0.048) and 0.811 cm3 in the left orbit (SD, 0.051), with no significant difference between right and left(p = 0.192). However, significant differences were observed between TAO patients and healthy individuals (p< 0.001). There was no significant difference between mean lacrimal gland volumes of males (0.812 cm3; SD,0.037) and females (0.816 cm3; SD, 0.029) (p = 0.513). There was a negative correlation between gland volumeand age in TAO patients (Pearson r = -0.479, p = 0.00). The subjective tearing (right: r = 0.244, p = 0.018;left: r = 0.226, p = 0.024), corneal superficial punctate keratopathy (right: r = 0.192, p = 0.040; left: r = 0.206, p= 0.036), and exophthalmometry (right: r = 0.182, p = 0.032; left: r = 0.180, p = 0.046) correlated with lacrimalgland volume. Conclusions: This study is the first to use CT images to calculate the lacrimal gland volume of Korean TAOpatients. In TAO patients, the lacrimal gland volume was notably increased compared to control subjects. Thelacrimal gland volume decreased with age, but there was no difference between gender and no difference betweenleft and right. The lacrimal gland volume correlated with subjective tearing, corneal superficial punctatekeratopathy and exophthalmometry.

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