지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 455 - 461 (7page)
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초록· 키워드
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Purpose: We investigated whether oxygen-induced retinopathy (OIR) results in changes in the protein expression of neuronal and inducible nitric oxide synthases (nNOS and iNOS, respectively) in rat model of OIR. In addition, we evaluated whether treatment of rats with triamcinolone acetonide (TA) prevents this response.
Methods: To promote OIR, Sprague-Dawley rats were exposed to hyperoxia from postnatal day 2 (P2) to P14. They were then returned to normoxia after P15. TA was injected into the right vitreous of P15 rats, while saline was injected into the left vitreous. At P18 the expression of nNOS and iNOS was determined using Western blotting and immunostaining techniques in retinas obtained from control rats.
Results: In P18 OIR rats, the abundance of nNOS and iNOS protein was significantly increased compared with controls. These increases were not observed in the retinas of rats treated with TA. The change in expression of nNOS and iNOS were specific to parvalbumin and glial fibrillary acidic protein-positive cells. Treatment with TA prevented the increased expression of nNOS and iNOS in all samples.
Conclusions: Hypoxia upregulates expression of nNOS and iNOS in OIR rat retinas, which is can be prevented by treatment with TA.
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참고문헌 (24)
참고문헌 신청
Abraham IM / 2001 / Action of glucocorticoids on survival of nerve cells: promoting neurodegeneration or neuroprotection? / J Neuroendocrinol 13 : 749 ~ 760
Almeida A / 1998 / Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion / Brain Res 790 : 209 ~ 216
Brafman A / 2004 / Inhibition of oxygen-induced retinopathy in RTP801-deficient mice / Invest Ophthalmol Vis Sci 45 : 3796 ~ 3805
Chemtob S / 1995 / Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics / J Appl Physiol 78 : 2039 ~ 2046
Dawson VL / 1991 / Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures / Proc Natl Acad Sci U S A 88 : 6368 ~ 6371
Almeida A / 1998 / Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion / Brain Res 790 : 209 ~ 216
Brafman A / 2004 / Inhibition of oxygen-induced retinopathy in RTP801-deficient mice / Invest Ophthalmol Vis Sci 45 : 3796 ~ 3805
Chemtob S / 1995 / Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics / J Appl Physiol 78 : 2039 ~ 2046
Dawson VL / 1991 / Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures / Proc Natl Acad Sci U S A 88 : 6368 ~ 6371
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