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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 210 - 215 (6page)
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초록· 키워드
오류제보하기
Background: Several studies have indicated that a nerve injury enhances the expression of the voltage-gated calcium channel α2δ1 subunit (Cavα2δ1) in sensory neurons and the dorsal spinal cord. This study examined whether NMDA receptor activation is essential for Cavα2δ1-mediated tactile allodynia in Cavα2δ1 over- expressing transgenic mice and L5/6 spinal nerve ligated rats (SNL). These two models show similar Cavα2δ1 upregulation and behavioral hypersensitivity, without and with the presence of other injury factors, respectively.
Methods: The transgenic (TG) mice were generated as described elsewhere (Feng et al., 2000). The left L5/6 spinal nerves in the Harlan Sprague Dawley rats were ligated tightly (SNL) to induce neuropathic pain, as described by Kim et al. (1992). Memantine 2 ㎎/㎏ (10 ㎕) was injected directly into the L5/6 spinal region followed by 10㎕ saline. Tactile allodynia was tested for any mechanical hypersensitivity.
Results: The tactile allodynia in the SNL rats could be reversed by an intrathecal injection of memantine 2 ㎎/㎏ at 1.5 hours. The tactile allodynia in the Cavα2δ1 over-expressing TG mice could be reversed by an intrathecal injection of memantine 2 ㎎/㎏ at 1.5, 2.0 and 2.5 hours.
Conclusions: The behavioral hypersensitivity was similar in the TG mice and nerve injury pain model, supporting the hypothesis that elevated Cavα2δ1 mediates similar pathways that underlie the pain states in both models. The selective activation of spinal NMDA receptors plays a key role in mediating the pain states in both the nerve-injury rats and TG mice.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Battaglia G / 1988 / Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey / J Comp Neurol 277 : 302 ~ 312
Coderre TJ / 1992 / The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury / J Neurosci 12 : 366
Davies J / 1982 / Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems / Comp Biochem Physiol C 72 :
Davies SN / 1987 / Evidence for involvement of N- methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat / Brain Res 424 : 402 ~ 406
Dickenson AH / 1987 / Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimula
Coderre TJ / 1992 / The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury / J Neurosci 12 : 366
Davies J / 1982 / Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems / Comp Biochem Physiol C 72 :
Davies SN / 1987 / Evidence for involvement of N- methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat / Brain Res 424 : 402 ~ 406
Dickenson AH / 1987 / Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimula
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