지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 23 - 29 (7page)
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초록· 키워드
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Background: Nefopam has shown an analgesic effect on acute pain including postoperative pain. The reuptake of monoamines including serotonin and noradrenaline has been proposed as the mechanism of the analgesic action of nefopam, but it remains unclear. Although alpha-adrenergic agents are being widely used in the perioperative period, the role of noradrenergic modulation in the analgesic effect of nefopam has not been fully addressed.
Methods: Changes in the antinociceptive effect of intrathecal (i.t.) nefopam against formalin-elicited flinching responses were explored in Sprague-Dawley rats pretreated with i.t. 6-hydroxydopamine (6-OHDA), which depletes spinal noradrenaline. In addition, antagonism to the effect of nefopam by prazosin and yohimbine was evaluated to further elucidate the antinociceptive mechanism of i.t. nefopam.
Results: Pretreatment with i.t. 6-OHDA alone did not alter the flinching responses in either phase of the formalin test, while it attenuated the antinociceptive effect of i.t. nefopam significantly during phase 1, but not phase 2. The antagonist of the alpha-2 receptor, but not the alpha-1 receptor, reduced partially, but significantly, the antinociceptive effect of i.t. nefopam during phase 1, but not during phase 2.
Conclusions: This study demonstrates that spinal noradrenergic modulation plays an important role in the antinociceptive effect of i.t. nefopam against formalin-elicited acute initial pain, but not facilitated pain, and this action involves the spinal alpha-2 but not the alpha-1 receptor.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Benarroch EE / 2008 / Descending monoaminergic pain modulation:bidirectional control and clinical relevance / Neurology 71 : 217 ~ 221
Bernatzky G / 1986 / Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats / Eur J Pharmacol 120 : 75 ~ 8
Coderre TJ / 1992 / The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury / J Neurosci 12 : 366
Esposito E / 1986 / Evidence of the involvement of dopamine in the analgesic effect of nefopam / Eur J Pharmacol 128 : 157 ~ 164
Fasmer OB / 1987 / Antinociceptive effects of (+/-)-, (+)- and (-)-nefopam in mice / J Pharm Pharmacol 39 : 508 ~ 511
Bernatzky G / 1986 / Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats / Eur J Pharmacol 120 : 75 ~ 8
Coderre TJ / 1992 / The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury / J Neurosci 12 : 366
Esposito E / 1986 / Evidence of the involvement of dopamine in the analgesic effect of nefopam / Eur J Pharmacol 128 : 157 ~ 164
Fasmer OB / 1987 / Antinociceptive effects of (+/-)-, (+)- and (-)-nefopam in mice / J Pharm Pharmacol 39 : 508 ~ 511
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