지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 56 - 60 (5page)
이용수
초록· 키워드
오류제보하기
Background: Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) has increasingly been used for the treatment of acne vulgaris and several studies have shown its clinical efficacy. However, ALA-PDT needs a relatively long incubation period and is frequently associated with adverse effects. Indole-3-acetic acid (IAA) has been introduced as a new photosensitizer for the treatment of acne in recent study.
IAA-PDT requires only a short incubation period and the procedure is relatively painless in contrast to ALA-PDT.
Objective: To investigate the efficacy and safety of IAA- PDT in the treatment of acne. Methods: Twenty-five patients with facial acne lesions were enrolled in this study. IAA-PDT was performed for five sessions at 1-week intervals (week 0∼4).
IAA was treated with 15 minute occlusion, and green light was given for 15 minutes. Clinical efficacy was determined by evaluating acne lesion counts, severity grading, and the Dermatology Life Quality Index (DLQI) at week 0, 2, 4, and 5. Sebum secretion and erythema index was measured by Sebumeter and Mexameter, respectively, at baseline and one week after each treatment session (week 1∼5). Histopathological examination was performed at baseline and week 5.
Adverse effects were recorded throughout the study. Results:All the patients completed the study. Numbers of both inflammatory and non-inflammatory acne lesions were significantly decreased. Acne severity grade and the DLQI showed significant reduction. Sebum secretion and erythema were also reduced. Histopathological examination showed a reduction in inflammatory reactions. No adverse effects were observed except for transient pruritus in one patient. Conclusion: PDT using IAA and green light was an effective, simple and safe treatment for acne.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Basra MK / 2008 / The Dermatology Life Quality Index 1994-2007: a comprehensive review of validation data and clinical results / Br J Dermatol 159 : 997 ~ 1035
Divaris DX / 1990 / Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with lo calized protopo
Folkes LK / 2001 / Oxidative activation of indole-3- acetic acids to cytotoxic species- a potential new role for plant auxins in cancer therapy / Biochem Pharmacol 61 : 129
Goldsmith MH / 1993 / Cellular signaling: new insights into the action of the plant growth hormone auxin / Proc Natl Acad Sci U S A 90 : 11442 ~ 11445
Greco O / 2000 / Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid / Cancer Gene Ther 7 : 1414 ~ 1420
Divaris DX / 1990 / Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with lo calized protopo
Folkes LK / 2001 / Oxidative activation of indole-3- acetic acids to cytotoxic species- a potential new role for plant auxins in cancer therapy / Biochem Pharmacol 61 : 129
Goldsmith MH / 1993 / Cellular signaling: new insights into the action of the plant growth hormone auxin / Proc Natl Acad Sci U S A 90 : 11442 ~ 11445
Greco O / 2000 / Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid / Cancer Gene Ther 7 : 1414 ~ 1420
이 논문의 저자 정보
최근 본 자료
댓글(0)
0