지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 597 - 601 (5page)
이용수
초록· 키워드
오류제보하기
Background: Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis. Objective: This study was conducted to identify additional genetic evidence of TRPS and hair morphogenesis from a TRPS patient. Methods: From one TRPS type I patient, we extracted RNA and profiled whole transcriptome in non-balding and balding scalp areas using high-throughput RNA sequencing. Results: We found a total of 26,320 genes, which comprised 14,892 known genes with new isoforms and 4,883 novel genes from the non-balding and balding areas. Among these, a total of 1,242 genes showed different expression in the two scalp areas (p＜0.05 and log2 fold-change ＞0). Several genes related to the skin and hair, alopecia, and the TRPS1 gene were validated by qRT-PCR. Twelve of 15 genes (KRT6C, KRTAP3-1, MKI67, GPRC5D, TYRP1, DSC1, PMEL, WIF1, SOX21, TINAG, PTGDS, and TRPS1) were down-regulated (10 genes: p＜0.01; SOX21 and PTGDS: p＞0.05), and the three other genes (HBA2, GAL, and DES) were up-regulated (p ＜0.01) in the balding scalp. Many genes related to keratin and hair development were down-regulated in the balding scalp of the TRPS type I patient. In particular, the TRPS1 gene might be related to androgen metabolism and hair morphogenesis.
Conclusion: Our result could suggest a novel perspective and evidence to support further study of TRPS and hair morphogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Anders S / 2015 / HTSeq--a Python framework to work with high-throughput sequencing data / Bioinformatics 31 : 166 ~ 169
Chang GT / 2004 / The TRPS1 transcription factor: androgenic regulation in prostate cancer and high expression in breast cancer / Endocr Relat Cancer 11 : 815 ~ 822
Fantauzzo KA / 2012 / Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis / Development 139 : 203 ~ 214
Flicek P / 2013 / Ensembl 2013 / Nucleic Acids Res 41 (Database issue) : D48 ~ D55
Gai Z / 2011 / The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles / Histol Histopathol 26 : 915 ~ 921
Chang GT / 2004 / The TRPS1 transcription factor: androgenic regulation in prostate cancer and high expression in breast cancer / Endocr Relat Cancer 11 : 815 ~ 822
Fantauzzo KA / 2012 / Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis / Development 139 : 203 ~ 214
Flicek P / 2013 / Ensembl 2013 / Nucleic Acids Res 41 (Database issue) : D48 ~ D55
Gai Z / 2011 / The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles / Histol Histopathol 26 : 915 ~ 921
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