지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 335 - 339 (5page)
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초록· 키워드
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Background: Topical photodynamic therapy (PDT) has been increasingly used to treat malignant skin tumors including the Bowen disease. However, patients could be displeased with the long incubation time required for conventional PDT. Objective: We evaluated the efficacy and safety of PDT with a short incubation time of ablative CO2 fractional laser pretreatment for treating Bowen disease. Methods: Ten patients were included. Just before applying the topical photosensitizer, all lesions were treated with ablative CO2fractional laser, following the application of methyl aminolevulinate and irradiation with red light (Aktilite CL 128). Histological confirmation, rebiopsy, and clinical assessments were performed. Adverse events were also recorded. Results: Five of the ten (50%) lesions showed a complete response (CR) within three PDT sessions. After four treatment sessions, all lesions except one penile shaft lesion (90%) achieved clinical and histological CR or clinical CR only. The average number of treatments to CR was 3.70±1.70. The treatments showed favorable cosmetic outcomes and no serious adverse events. Conclusion: The results suggest that pretreatment with an ablative fractional CO2 laser before PDT has similar treatment efficacy and requires a shorter photosensitizer incubation time compared with the conventional PDT method.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Borelli C / 2007 / Effect of subcutaneous infiltration anesthesia on pain in photodynamic therapy: a controlled open pilot trial / Dermato
Calzavara-Pinton PG / 2008 / Methylaminolaevulinatebased photodynamic therapy of Bowen's disease and squamous cell carcinoma / Br J Dermatol 159 : 137 ~ 144
Clementoni MT / 2010 / Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light / Lasers Surg Med 42 : 150 ~ 159
Cox NH / 1999 / Guidelines for management of Bowen's disease. British Association of Dermatologists / Br J Dermatol 141 : 633 ~ 641
Cox NH / 2007 / Guidelines for management of Bowen's disease: 2006 update / Br J Dermatol 156 : 11 ~ 21
Calzavara-Pinton PG / 2008 / Methylaminolaevulinatebased photodynamic therapy of Bowen's disease and squamous cell carcinoma / Br J Dermatol 159 : 137 ~ 144
Clementoni MT / 2010 / Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light / Lasers Surg Med 42 : 150 ~ 159
Cox NH / 1999 / Guidelines for management of Bowen's disease. British Association of Dermatologists / Br J Dermatol 141 : 633 ~ 641
Cox NH / 2007 / Guidelines for management of Bowen's disease: 2006 update / Br J Dermatol 156 : 11 ~ 21
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