지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 468 - 473 (6page)
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초록· 키워드
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Background: Severe pruritus is the primary symptom in atopic dermatitis (AD). Recently, the novel cytokine IL-31has been implicated in the itching associated with AD.
Objective: We performed this study to determine whether IL-31 serum levels are elevated in AD patients and to better characterize the relationship between serum IL-31 level and other established laboratory parameters. Methods: We recruited 55 AD patients, 34 with allergic type AD and 21with non-allergic type AD, and 38 healthy, non-atopic controls. We checked the laboratory values, severity score,and serum IL-31 levels in all patients and controls, and IL-31mRNA levels in lesion skin were measured in 13 subjects with AD and in four controls. Results: AD patients displayed significantly higher levels of serum IL-31 that were associated with serum IgE, disease severity, and subjective itch intensity. In AD patients, IL-31 mRNA levels from the lesional skin samples also correlated with serum IL-31 level.
Conclusion: IL-31 is likely one of the many mediators inducing inflammation and pruritus in AD. Although our limited sample size prevents us from making any definitive conclusions, our data demonstrate a strong correlation between IL-31 mRNA level and serum IL-31 protein level,which has never been reported before. Moreover, we found correlations between serum IL-31 level and serum IgE,eosinophil cationic protein, disease severity, and subject itch intensity in certain degrees in AD patients. (Ann Dermatol 23(4) 468∼473, 2011)
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참고문헌 (19)
참고문헌 신청
/ 1993 / Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis / Dermatology 186 : 23 ~ 31
Bilsborough J / 2006 / IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis / J Allergy Clin Immunol 117 : 41
Chan LS / 2001 / Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopi
Chi KH / 2001 / Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma / Oncology 60 : 110 ~ 115
Dillon SR / 2004 / Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice / Nat Immunol 5 : 752 ~ 760
Bilsborough J / 2006 / IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis / J Allergy Clin Immunol 117 : 41
Chan LS / 2001 / Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopi
Chi KH / 2001 / Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma / Oncology 60 : 110 ~ 115
Dillon SR / 2004 / Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice / Nat Immunol 5 : 752 ~ 760
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