지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 727 - 737 (11page)
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초록· 키워드
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Background: Blastic plasmacytoid dendritic cell neoplasm (BPDCN), which is derived from the precursor of plasmacytoid dendritic cells, is a rare and highly aggressive hematologic malignancy. It has only recently been recognized as a distinct entity. BPDCN characteristically has a predilection for cutaneous involvement. Objective: The aim of this study was to describe the clinical and pathological features of BPDCN, and to review the treatment courses to analyze the prognosis and the optimal therapeutic approach. Methods: We retrospectively reviewed seven BPDCN cases registered in the Samsung Medical Center database between January 2010 and December 2014. Results: The median age of the patients was 52 years (range, 18∼79 years), and six patients were male. The clinical staging was as follows: skin (n=5), lymph node (n=6), bone marrow (n=4), and peripheral blood (n=2). The skin manifestations were bruise-like tumefaction (n=4), erythematous nodule (n=4), or multiple erythematous papules (n=1). The pathological evaluation revealed dense diffuse or nodular infiltration of neoplastic cells, which were positive for CD4, CD56, and CD123 in the immunohistochemical analysis. Six patients received multiagent chemotherapy as the first-line treatment, alone (n=4), or followed by stem cell transplantation (SCT, n=1) or concurrent radiotherapy (n=1). The median progression-free survival after the first-line treatment was 6 months (range, 2 ∼12 months). Conclusion: Three different skin manifestations were observed, with pathological features analogous to each other. All patients who received chemotherapy without SCT achieved partial or complete response but experienced relapse. Furthermore, they showed various clinical courses irrelevant to the cutaneous involvement.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Adachi M / 1994 / High expression of CD56 (N-CAM) in a patient with cutaneous CD4-positive lymphoma / Am J Hematol 47 : 278 ~ 282
An HJ / 2013 / Blastic plasmacytoid dendritic cell neoplasm: a single-center experience / Ann Hematol 92 : 351 ~ 356
Argyrakos T / 2004 / Blastic natural killer (NK)-cell lymphoma: report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the
Borchiellini D / 2013 / Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature / J Eur Acad Dermatol Venereol 27 : 1176 ~ 1181
Bueno C / 2004 / Incidence and characteristics of CD4(+)/HLA DRhi dendritic cell malignancies / Haematologica 89 : 58 ~ 69
An HJ / 2013 / Blastic plasmacytoid dendritic cell neoplasm: a single-center experience / Ann Hematol 92 : 351 ~ 356
Argyrakos T / 2004 / Blastic natural killer (NK)-cell lymphoma: report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the
Borchiellini D / 2013 / Blastic plasmacytoid dendritic cell neoplasm: a report of four cases and review of the literature / J Eur Acad Dermatol Venereol 27 : 1176 ~ 1181
Bueno C / 2004 / Incidence and characteristics of CD4(+)/HLA DRhi dendritic cell malignancies / Haematologica 89 : 58 ~ 69
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