Dosimetric characterization and commissioning of a superfi cial electronic brachytherapy device for skin cancer treatment

박한범; 김현남; 이주혁; 이익재; 최진현; 조성오

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자료유형: 학술저널

저자정보: 박한범 김현남 이주혁 이익재 최진현 조성오

저널정보: 한국원자력학회 Nuclear Engineering and Technology Nuclear Engineering and Technology 제50권 제6호

발행연도: 2018.1

수록면: 937 - 943 (7page)

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연구결과

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Background: This work presents the performance of a novel electronic brachytherapy (EBT) device andradiotherapy (RT) experiments on both skin cancer cells and animals using the device. Methods and materials: The performance of the EBT device was evaluated by measuring and analyzingthe dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells wasanalyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice. Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. Theresults of the RT experiments on the skin cancer cells show that a significant apoptosis inductionoccurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results ofthe animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growthand that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same asthat induced by irradiation with a high-energy electron beam. Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancerwith a conventional linear accelerator. Consequently, the EBT device can be practically used for humanskin cancer treatment in the near future.

참고문헌 (26)

참고문헌 신청

H.W. Rogers / 2015 / Incidence estimate of nonmelanoma skin cancer (Keratinocyte Carcinomas) in the U.S. Population, 2012 / JAMA Dermatol 151:1081~1086

R.S. Stern / 2010 / Prevalence of a history of skin cancer in 2007: results of an incidence-based model / Arch. Dermatol 146:279~282

R.G. Freeman / 1964 / The treatment of skin cancer. A statistical study of 1,341 skin tumors comparing results obtained with irradiation, surgery, and curettage followed by electrodesiccation / Cancer 17:535~538

D. L. Shriner / 1998 / Mohs micrographic surgery / J. Am. Acad. Dermatol 39:79~97

N. Heidary / 2008 / Chemotherapeutic agents and the skin: an update / J. Am. Acad. Dermatol 58:545~570

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