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The induction of heme oxygenase-1(HO-1) by UV radiation provides a protective defense against oxidative stress, and has been well demonstrated in UVA-irradiated skin, but not UVB. In this study, we show that the UVB radiation can be attributed to the induction of cutaneous HO-1. The expression of HO-1 mRNA was assessed in vivo by reverse transcription-polymerase chain reaction(RT-PCR) analysis, and HO enzyme activity was measured in microsomal preparation from irradiated mice. The mRNA level of HO-1 increases in liver and skin from 1d to 3d after UVB(3KJ/m²) exposure. The results of gene expression were same pattern of HO enzyme activity in skin, but not in liver. HO-1 mRNA in liver resulted in a progressive increase to 4d after UVB exposure, but HO activity in liver increased to 2d. This finding indicates that UVB radiation is an important inducer of HO-1 and increases in HO activity may protect tissue directly or indirectly from oxidative stress.
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참고문헌 (21)
참고문헌 신청
[학술지(
Allanson, M. / 2004 / Immunoprotective UVA(320-400nm) irradiation upregulates Heme Oxygenase-1 in the dermis and epidermis of hairless mouse skin / The Journal of Investigati
Applegate, L. A. / 1995 / Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: Impl
Basu-Modak, S. / 1996 / Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene / Free Radical Biology and Medicine 20 (7) : 887 ~ 897
Cooper, K. L. / 2007 / Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production / Toxicology
Allanson, M. / 2004 / Immunoprotective UVA(320-400nm) irradiation upregulates Heme Oxygenase-1 in the dermis and epidermis of hairless mouse skin / The Journal of Investigati
Applegate, L. A. / 1995 / Two genes contribute to different extents to the heme oxygenase enzyme activity measured in cultured human skin fibroblasts and keratinocytes: Impl
Basu-Modak, S. / 1996 / Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene / Free Radical Biology and Medicine 20 (7) : 887 ~ 897
Cooper, K. L. / 2007 / Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production / Toxicology
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