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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 285 - 291 (7page)
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초록· 키워드
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This study was performed to investigate the effects of Chitosan on the nickel poisoning in rats. In the study, 150 male Sprague-Dawley were used. The experimental groups were divided into four: A (30 mg/L nickel), B (30 mg/L nickel+0.2% Chitin, Chitosan and Dithiocarbamate Chitosan), C (30 mg/L nickel+0.4% Chitin, Chitosan and Dithiocarbamate Chitosan), D (30 mg/L nickel+0.8%Chitin, Chitosan and Dithiocarbamate Chitosan).
The results were as flows;
1. The nickel concentration in the livers of the control group (A) was 0.153~0.186 mg/kg but the nickel concentration in the livers of the experimental decreased during the experimental period (P<0.05).
2. Metallothionenin levels in rat liver were 2.77~3.25 ug/g wet,wt in control group (A), but were 2.89~3.51 ug/g wet,wt (B), 2.97~3.62 ug/g wet,wt (C), 2.68~3.68 ug/g wet,wt (D). Resectively in the experimental groups. The experimental groups were inclined to increase compare to the control group (P<0.05).
In conclusion, this study revealed a preventive effect of Chitin, Chitosan and Dithiocarbamate Chitosan against nickel toxicity.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Cha, B. S. / 2000 / Comparative Hepatotoxicity Assessment of Cadmium and Nickel with Isolated Perfused Rat Liver / Korean J. Perv. Med 33 (1) : 117 ~ 124
Cherian, M.G. / 1983 / Cellular adaptation in metal toxicolgy and metallothionein / Toxicology 25 : 1 ~ 15
Eaton, D. L. / 1966 / Evaluation of the Cd/ hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues / Toxicol. Appl. Pharmacol 5 : 176
Eaton, D. L. / 1982 / Evaluation of Cd/ henolobin affinity assay for the rapid determination of metallothionein in biological tissues / Toxicol Appl Pharmacol 66 : 134 ~
Hall L. D. / 1980 / Enhancement of the metal chelating properties of chitin and chitosan / Carbohydrate Research 83 : C5 ~ C7
Cherian, M.G. / 1983 / Cellular adaptation in metal toxicolgy and metallothionein / Toxicology 25 : 1 ~ 15
Eaton, D. L. / 1966 / Evaluation of the Cd/ hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues / Toxicol. Appl. Pharmacol 5 : 176
Eaton, D. L. / 1982 / Evaluation of Cd/ henolobin affinity assay for the rapid determination of metallothionein in biological tissues / Toxicol Appl Pharmacol 66 : 134 ~
Hall L. D. / 1980 / Enhancement of the metal chelating properties of chitin and chitosan / Carbohydrate Research 83 : C5 ~ C7
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