지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Osteoporosis is a prevalent problem amongst the elderly. Bone mineral density (BMD) obtained from dual X-ray absorptiometry (DXA) is the gold standard in diagnosing osteopenia (-1.0 < t < -2.5) and osteoporosis (t > -2.5). However, following osteoporosis therapy, increases in BMD may be unreliable. Although hip fracture risk can be reduced with the aid of drugs, treated patients still face considerable risk as most people who sustain hip fracture do not have generalized osteoporosis. A study of the local distribution of bone mass was necessary as they contribute to the geometry and consequently the bone strength. Methods: By identifying the respective regions in the femoral neck, the geometric changes were localized and differed between each patient, proving that drug treatment elicits local changes in mean outer radius and mean cortical thickness. Numerical analysis also validated the above findings, where critical strain regions were predicted at similar zones and this is coherent with the fact that reduced thickness of the cortical bone has been related to increased risk of fracture initiation. Results: Hence, from individual radar plots, we can determine if the effect of drugs had outweighed the effect of aging. We can then propose a course of treatment drug better suited for the patient in the clinical scenario. Conclusion: Clinically, little conclusion can be drawn from just the BMD in osteopenic / osteoporotic patients. This emphasizes the necessity of using geometry and structure to predict fracture risk. Focusing on a patient specific analysis at a local level will improve diagnosis of osteoporosis and ultimately fracture prediction. (J Menopausal Med 2014;20:52-56)
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참고문헌 (11)
참고문헌 신청
Anitha D / 2013 / Implications of local osteoporosis on the efficacy of anti-resorptive drug treatment: a 3-year follow-up finite element study in risedronate-treated women /
Carpenter RD / 2011 / Effects of age and sex on the strength and cortical thickness of the femoral neck / Bone 48 : 741 ~ 747
Kanis JA / 1994 / The diagnosis of osteoporosis / Bone Miner Res 9 : 1137 ~ 1141
Keyak JH / 2001 / Improved prediction of proximal femoral fracture load using nonlinear finite element models / Med Eng Phys 23 : 165 ~ 173
McClung MR / 2001 / Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group / Med 344 : 333 ~ 340
Carpenter RD / 2011 / Effects of age and sex on the strength and cortical thickness of the femoral neck / Bone 48 : 741 ~ 747
Kanis JA / 1994 / The diagnosis of osteoporosis / Bone Miner Res 9 : 1137 ~ 1141
Keyak JH / 2001 / Improved prediction of proximal femoral fracture load using nonlinear finite element models / Med Eng Phys 23 : 165 ~ 173
McClung MR / 2001 / Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group / Med 344 : 333 ~ 340
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