지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Population pharmacokinetics for gentamicin were compared with 20 Korean patients (14 male and 6 female) and 25Caucasian appendicitis patients (16 male and 9 female). Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion.
Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant(K), the slope(KS) of the relationship between K versus creatinine clearance(Ccr), the apparent volume of distribution (V), the slope(VS) of the relationship between V versus weight, gentamicin clearance(CL) and the slope(CS) of the relationship between CL versus Ccr and the V. The output includes two marginal probability density function(PDF), means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS)were 0.402±0.129 hr^(-1) (0.00486±0.00197 [hr·mL/min/1.73 m²]^(-1) and 0.425±0.137 hr^(-1)(0.00432±0.00168 [hr·mL/min/1.73 m²]^(-1)for Korean and Caucasian populations, respectively. The mean V(VS) were not different at 14.3±3.69 L(0.241±0.0511 L/kg) and 15.8±4.81 L (0.236±0.0531 L/kg) for Korean and Caucasian populations, respectively (P>0.2). The mean CL(CS) were 5.68±1.69 L/hr (0.0714±0.0222 L/kg[hr·mL/min/1.73 m²]) and 6.29±1.84 L/hr (0.0629±0.0189 L/kg[hr·mL/min/1.73 m²]) for Korean and Caucasian populations, respectively. There are no differences in gentamicin pharmacokinetics between Korean and Caucasian appendicitis patients.
목차
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참고문헌 (24)
참고문헌 신청
Antal EJ / 1989 / An
Biggeri A / 2000 / Non-parametric maximum likelihood estimators for disease mapping / Stat Med 15 : 2539 ~ 2546
Burm JP / 2005 / The influence of weight with assay error on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis pa
Bustad A / 2006 / Parametric and nonparametric population methods: their comparative performance in analysing a clinical dataset and two Monte Carlo simulation studies / Cli
Erdmann SM / 1991 / An updated comparison of drug dosing methods. Part III: amionglycoside antibiotics / Clin Pharmacokinet 20 : 374 ~ 379
Biggeri A / 2000 / Non-parametric maximum likelihood estimators for disease mapping / Stat Med 15 : 2539 ~ 2546
Burm JP / 2005 / The influence of weight with assay error on gentamicin pharmacokinetics using the Bayesian and nonlinear least square regression analysis in appendicitis pa
Bustad A / 2006 / Parametric and nonparametric population methods: their comparative performance in analysing a clinical dataset and two Monte Carlo simulation studies / Cli
Erdmann SM / 1991 / An updated comparison of drug dosing methods. Part III: amionglycoside antibiotics / Clin Pharmacokinet 20 : 374 ~ 379
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