지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The quinolones are broad-spectrum antibiotics and enhanced antimicrobial activity has extended the use of the quinolones beyond the traditional indications for quinolone antibiotics in the treatment of urinary tract infections. The quinolones are effective in a wider variety of infectious diseases, including skin and respiratory infections. Because of their excellent safety and tolerability, they have become popular alternatives to penicillin and cephalosporin derivatives in the treatment of various infections. A retrospective study was performed to evaluate efficacy and safety of IV quinolones for inpatient use. Total 117 patients who administerd quinolones for longer than 3 continuous days at community hospital from October 1st, 2008 to December 31st, 2008 were reviewed. The criterias for drug evaluation were included the validation of indication, outcome, dosage and side effects. In the results, ciprofloxacin 13 (total 93), levofloxacin 3(total 59) and moxifloxacin 2 (total 19) cases were not met the criterias based on the culture results. Major indications were pneumonia (ciprofloxacin 16.3%, levofloxacin 67.8%, moxifloxacin 84.2%), urinary tract infection (ciprofloxacin 44.1%), skin infection (ciprofloxacin 7.5%, levofloxacin 20.3%, moxifloxacin 10.5%), intra-abdominal infection (ciprofloxacin 10.8%, moxifloxacin 5.3%), etc.. In the results of quinolone monotherapy, the frequencies were each ciprofloxacin 74.2%, levofloxacin 50.8% and moxifloxacin 47.4%. In the results of dosage validation, the validities were each ciprofloxacin 54.8%, levofloxacin 94.9% and moxifloxacin 100.0%. In the results of duration validation, the validities were each ciprofloxacin 59.1%, levofloxacin 78.0% and moxifloxacin 89.5%. Adverse drug reactions were reported for total 49 cases and those were gastrointestinal tract effects including nausea, vomiting, diarrhea and central nervous system effects including headache, dizziness. In summary, the quinolones appropriately used for hospitalized patients based on this study. A focused approach emphasizing "correct use of quinolones" may reduce development of antimicrobial resistance and maximize class efficacy. Consequently, correct use of antibiotics will contribute to decrease medical expenses for person and community.
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참고문헌 (17)
참고문헌 신청
Carrie, Ag / 2006 / Outpatient Treatment of Community-acquired Pneumonia: Evolving Trends and a Focus on Fluoroquinolones. (PDF) / The Canadian Journal of Clinical Pharmacolo
Jacobs M / 2005 / Worldwide Overview of Antimicrobial Resistance / International Symposium on Antimicrobial Agents and Resistance
Joseph M. Blondeau / 1999 / A Review of the Comparative invitro Activities of 12 Antimicrobial Agents, with a Focus on Five New Respiratory Quinolones / Journal of Antimicrib
Judith A, Aberg / 2006 / Infectious Diseases Handbook, 6th Edition / Lexi-Comp, Inc
Lescher, G. Y / 1962 / 1, 8-Naphthyridine Derivatives: a New Class of Chemotherapeutic Agents / Journal of Medical Phamaceutical Chemistry 5 : 1063 ~ 1068
Jacobs M / 2005 / Worldwide Overview of Antimicrobial Resistance / International Symposium on Antimicrobial Agents and Resistance
Joseph M. Blondeau / 1999 / A Review of the Comparative invitro Activities of 12 Antimicrobial Agents, with a Focus on Five New Respiratory Quinolones / Journal of Antimicrib
Judith A, Aberg / 2006 / Infectious Diseases Handbook, 6th Edition / Lexi-Comp, Inc
Lescher, G. Y / 1962 / 1, 8-Naphthyridine Derivatives: a New Class of Chemotherapeutic Agents / Journal of Medical Phamaceutical Chemistry 5 : 1063 ~ 1068
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