지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Oxaliplatin is a tolerable and effective drug of choice in the treatment of advanced or metastatic gastric cancer. However, it has many dose-limiting neurotoxicities. This study was performed to assess the incidence and types of oxaliplatin-related neurotoxicities. Sixty-four patients receiving oxaliplatin-involved regimen as salvage therapy on metastatic gastric cancer or as the first-line therapy on advanced gastric cancer were evaluated during the period between September 1, 2006 and February 29, 2008. The patients were treated with oxaliplatin 100 mg/m2 and leucovorin 100 mg/m2 simultaneously as 2-hour-lasting infusion on Day-1 followed by 5-FU 1200 mg/m2 as a 22-hour-lasting continuous infusion both on Day-1 and Day-2 by every other week. We developed questionnaires to evaluate patient-recognized neurotoxic
symptoms rather than the observer-described events. Surveys were completed at bedside or via telephone interview. Acute and chronic neurotoxicities were graded according to the National Cancer Institute Common Toxicity Criteria (NCI-CTC, version 3) as well as the Oxaliplatin-specific Neurotoxicity Scale. The Grade-3 neuropathy was reported in 19% of the patients (n=12) and grade-1/2 neuropathy occurred in 70% (n=45). The most common symptom was cold-related dysesthesia (83%) regarded as nociperception by the patients. Some patients (19%) experienced
functional impairment affecting activities of daily living such as writing, buttoning, and walking. Even though 74% of the patients (42/57) were prescribed with gabapentin to reduce these peripheral symptoms, it did not appear to derive any benefit from this medication. It is suggested that notify the patients about their oxaliplatin-associated, debilitating symptoms, and educate them any self-care strategy at the initiating phase of the chemotherapy. Moreover, it needs to design the intervention studies regarding the prevention and management of the peripheral neuropathy.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
/ / 2003-2005년 암발생률 및 1993-2005년 발생자의 암생존율
Al-Batran SE / 2004 / Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer / J Clin Oncol 22 : 658 ~ 663
Cassidy J / 2002 / Oxaliplatin-related side effects: characteristics and management / Semin Oncol 29 : 11 ~ 20
Cavanna L / 2006 / Oxaliplatin in combination with 5-fluorouracil and leucovorin in patients with metastatic gastric cancer / Am J Clin Oncol 29 : 371 ~ 375
De Gramont A / 2000 / Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer / J Clin Oncol 18 : 2938 ~ 2947
Al-Batran SE / 2004 / Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer / J Clin Oncol 22 : 658 ~ 663
Cassidy J / 2002 / Oxaliplatin-related side effects: characteristics and management / Semin Oncol 29 : 11 ~ 20
Cavanna L / 2006 / Oxaliplatin in combination with 5-fluorouracil and leucovorin in patients with metastatic gastric cancer / Am J Clin Oncol 29 : 371 ~ 375
De Gramont A / 2000 / Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer / J Clin Oncol 18 : 2938 ~ 2947
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Efficacy and Safety of Oxaliplatin, 5-Fluorouracil, and Folinic Acid Combination Chemotherapy as First-Line Treatment in Metastatic or Recurrent Gastric Cancer
Cancer Research and Treatment
2011 .01
-
Hypersensitivity Reactions to Oxaliplatin
Cancer Research and Treatment
2006 .01
-
직장암 환자에서 Oxaliplatin 투여로 인한 혈관부종 발생 증례 보고
한국임상약학회지
2011 .01
-
Oxaliplatin with Biweekly Low Dose Leucovorin and Bolus and Continuous Infusion of 5-fluorouracil (Modified FOLFOX 4) as a Salvage Therapy for Patients w ith Advanced Gastric Cancer
Cancer Research and Treatment
2005 .01
-
Oxaliplatin, 5-FU, Folinic Acid as First-line Palliative Chemotherapy in Elderly Patients with Metastatic or Recurrent Gastric Cancer
Cancer Research and Treatment
2007 .01
-
Effects of Analgecine on Oxaliplatin-Induced Neurotoxicity in Patients with Gastrointestinal Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Outcomes of Modified FOLFOX-6 as First Line Treatment in Patients with Advanced Gastric Cancer in a Single Institution; Retrospective Analysis
Cancer Research and Treatment
2010 .01
-
진행성 위암 환자에서 1차 요법으로 FOLFOX-4 병합화학 약물치료의 효과와 안정성
대한내과학회지
2012 .01
-
Phase II Study of Oxaliplatin, 5-fluorouracil, and Leucovorin in Relapsed or Metastatic Colorectal Cancer as Second Line Therapy
Cancer Research and Treatment
2006 .01
-
5-Fluorouracil, Leucovorin과 병용 투여된 Oxaliplatin의 Dose Intensity가 재발된 전이성 대장암 치료에 미치는 영향
한국임상약학회지
2004 .01
-
Clinical Features of Oxaliplatin Induced Hypersensitivity Reactions and Therapeutic Approaches
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
A case of advanced gastric cancer with hepatic metastases successfully treated with oxaliplatin/Leucovorin/5-FU
대한임상종양학회 학술대회지
2007 .09
-
Oxaliplatin을 투여 받는 대장암 환자의 우울, 불안, 사회적지지, 항암제 지식수준이 말초신경병증에 미치는 영향
임상간호연구
2013 .01
-
Prevalence of Oxaliplatin-induced Chronic Neuropathy and Influencing Factors in Patients with Colorectal Cancer in Iran
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Combination Chemotherapy of Oxaliplatin, 5-Fluorouracil and Low Dose Leucovorin in Patients with Advanced Colorectal Cancer
Cancer Research and Treatment
2005 .01
-
Hypersensitivity reactions associated with oxaliplatin in patients with colorectal cancer
대한임상종양학회 학술대회지
2010 .09
-
Oxaliplatin with Biweekly, Low Dose Leucovorin and Bolus and Continuous Infusion 5-fluorouracil (Modified FOLFOX 4) as First-line Therapy for Patients with Metastatic Colorectal Cancer
Cancer Research and Treatment
2004 .01
-
Cisplatin, Carboplatin, Oxaliplatin 투여로 인한 말초신경병증에 대한 평가
한국임상약학회지
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0