지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: To investigate adverse drug reactions (ADR) and causative drugs in the elderly 65 years of age or older,using Korean spontaneous reporting adverse events reporting database from June 2009 to December 2010. Methods: We estimated the association between ADRs and implicated medications by calculating a proportional reportingratio (PRR), reporting odds ratio (ROR), and information component (IC). We reexamined the most frequentlyimplicated medications and ADRs, and the seriousness of ADRs. Then, we assessed reports and concordant rate ofADRs due to medications designated as “high-risk” in elderly by 2012 healthcare effectiveness data and information set(HEDIS) or “potentially inappropriate” by 2012 American Geriatrics Society updated Beers criteria for potentially inappropriatemedications (PIMs). Results: Among 15,484 elderly reports, data-mining analysis by PRR, ROR and ICshowed that 421 drug-ADR pairs were detected as signals (3,189). The most frequently reported ADR and causativedrug were urticaria (470) and contrast media agents (647), respectively. One hundred eighty nine ADR cases weregraded as serious. Twenty-two kinds of high-risk medications were shown to be implicated in only 0.9% of ADRs. Only thirty-nine cases were consistent with 2012 Beers criteria or HEDIS. Conclusion: These results suggest that managementof the other medications including contrast media agents as well as close monitoring of PIMs are necessary forreducing ADRs in the elderly.
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참고문헌 (19)
참고문헌 신청
American Geriatrics Society 2012 Beers Criteria Update Expert Panel. / 2012 / American Geriatrics Society updated Beers Criteria for Potentially inappropriate medication use
Beijer HJ. / 2002 / Hospitalizations caused by adverse drug reactions(ADR) : a meta-analysis of observational studies / Pharm World Sci 24 : 46 ~ 54
Budnitz DS. / 2011 / Emergency Hospitalizations for adverse drug Events in older Americans / N Engl J Med 65 : 2002 ~ 2012
Christiansen C. / 2005 / X-ray contrast media : an overview / Toxicology 209 : 185 ~ 187
Egberts AC. / 2002 / Use of measures of disproportionality in pharmacovigilance : three Dutch examples / Drug Saf 25 : 453 ~ 458
Beijer HJ. / 2002 / Hospitalizations caused by adverse drug reactions(ADR) : a meta-analysis of observational studies / Pharm World Sci 24 : 46 ~ 54
Budnitz DS. / 2011 / Emergency Hospitalizations for adverse drug Events in older Americans / N Engl J Med 65 : 2002 ~ 2012
Christiansen C. / 2005 / X-ray contrast media : an overview / Toxicology 209 : 185 ~ 187
Egberts AC. / 2002 / Use of measures of disproportionality in pharmacovigilance : three Dutch examples / Drug Saf 25 : 453 ~ 458
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