지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
This study examined the effects of quercetin on corneal opacity caused by corneal edema by suppressing the damage on corneal endothelial cell, which was induced by mitomycin-C (MMC). In the MMC-treated group, the number of keratocytes was noticeably fewer compared to that of other groups. Although this group showed normal amount of fiber in the corneal stroma, the thickness was shown to be very thick and the alignment of the corneal endothelial cells that worked as the barrier against aqueous humor was irregular. According to such results, it was known that corneal opacity induced by MMC is not caused by proliferation of keratocytes, but by corneal edema triggered by the infiltration of aqueous humor. In the MMC+quercetin and quercetin+MMC-treated groups, the number of keratocytes was higher and polymorphonuclear leukocytes infilteration was lower significantly compared to that of the MMC-treated group. Although the amounts of fiber and endothelioid cell arrangement were normal, there was more space observed in the corneal stroma. Nonetheless, these groups showed significantly lower stromal thickness compared to that of the MMC group. In conclusion, quercetin has the effect on the reduction of corneal opacity caused by corneal edema that work MMC-induced damage to the corneal endothelial cells.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Anton R / 1988 / Flavonoids and traditional medicine / Prog. Clin. Biol. Res 280 : 423 ~ 439
Brown J P / 1980 / A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds / Mutat. Res 75 : 243 ~ 277
Buckley-Sturrock A / 1989 / Differential stimulation of collagenase and chemotatic activity in fibroblasts derived from rat wound repair tissue and human skin by growth facto
Carones F / 2002 / Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy / J. Cataract Refract. Surg 28 : 2088 ~ 2095
Chang S W / 2004 / Early corneal edema following topical application of mitomycin-C / J. Cataract Refract. Surg 30 : 1742 ~ 1750
Brown J P / 1980 / A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds / Mutat. Res 75 : 243 ~ 277
Buckley-Sturrock A / 1989 / Differential stimulation of collagenase and chemotatic activity in fibroblasts derived from rat wound repair tissue and human skin by growth facto
Carones F / 2002 / Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy / J. Cataract Refract. Surg 28 : 2088 ~ 2095
Chang S W / 2004 / Early corneal edema following topical application of mitomycin-C / J. Cataract Refract. Surg 30 : 1742 ~ 1750
이 논문의 저자 정보
최근 본 자료
댓글(0)
0