지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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With wide use of nano-materials, it is increasingly important to address their potential toxicity to mammalian cells. However, toxic effects of these materials have been mainly assessed by the cell survival assays. Considering that mitochondrial morphology and quality are highly sensitive to the condition of the cells, and the impairment of mitochondrial function greatly affect the survival of cells, here we tested the impact of multi-walled carbon nanotubes (MWNT) on the survival, mitochondrial morphology, and their membrane potential in HeLa cells. Interestingly, although MWNT did not induce cell death until 24 hours as assessed by pyknotic cell assay, mitochondrial length was elongated and the mitochondrial membrane potential was significantly reduced by exposure of HeLa cells to MWNT. These results suggest that MWNT exposure is potentially harmful to the cell, and the mechanism how MWNT alters mitochondrial quality should be further explored to assess the safety of MWNT use.
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참고문헌 (28)
참고문헌 신청
Aguer C / 2011 / Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells / PLOS ONE 6 : e28536 ~
Al Faraj A / 2010 / Long-term follow-up of lung biodistribution and effect of instilled SWCNTs using multiscale imaging techniques / Nanotechnology 21 : 175103 ~
Bachtold A / 2001 / Logic circuits with carbon nanotube transistors / Science 294 : 1317 ~ 1320
Bates K / 2013 / Carbon nanotubes as vectors for gene therapy: past achievements, present challenges and future goals / Adv. Drug Deliver Rev 65 : 2023 ~ 2033
Benard G / 2007 / Mitochondrial bioenergetics and structural network organization / J. Cell Sci 120 : 838 ~ 848
Al Faraj A / 2010 / Long-term follow-up of lung biodistribution and effect of instilled SWCNTs using multiscale imaging techniques / Nanotechnology 21 : 175103 ~
Bachtold A / 2001 / Logic circuits with carbon nanotube transistors / Science 294 : 1317 ~ 1320
Bates K / 2013 / Carbon nanotubes as vectors for gene therapy: past achievements, present challenges and future goals / Adv. Drug Deliver Rev 65 : 2023 ~ 2033
Benard G / 2007 / Mitochondrial bioenergetics and structural network organization / J. Cell Sci 120 : 838 ~ 848
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