지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Neurons utilize a large quantity of energy for their survival and function, and thereby require active mitochondrial function. Mitochondrial morphology shows dynamic changes, depending on the cellular condition, and mitochondrial dynamics are required for neuronal development and function. In this study, we found that the length of mitochondria in the distal axon is significantly shorter than that of mitochondria in dendrites or proximal axons of cerebral cortical neurons, and the reason for this difference is the local fission within the axon. We also found that suppression of Drp1, a key regulator of mitochondrial fission, resulted in significant elongation of mitochondria in axons. Collectively, these results suggest that local mitochondrial fission within the axon contributes to region-dependent mitochondrial length differences in the axons of cortical neurons.
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참고문헌 (19)
참고문헌 신청
Amiri M / 2008 / Mitochondrial biogenesis in the axons of vertebrate peripheral neurons / Dev Neurobiol 68 : 1348 ~ 1361
Bereiter-Hahn J / 1994 / Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria / Microsc Res Tech 27 : 198 ~ 219
Chan DC / 2006 / Mitochondrial fusion and fission in mammals / Annu Rev Cell Dev Biol 22 : 79 ~ 99
Collins TJ / 2002 / Mitochondria are morphologically and functionally heterogeneous within cells / EMBO J 21 : 1616 ~ 1627
Davies VJ / 2007 / Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function / Hum Mol
Bereiter-Hahn J / 1994 / Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria / Microsc Res Tech 27 : 198 ~ 219
Chan DC / 2006 / Mitochondrial fusion and fission in mammals / Annu Rev Cell Dev Biol 22 : 79 ~ 99
Collins TJ / 2002 / Mitochondria are morphologically and functionally heterogeneous within cells / EMBO J 21 : 1616 ~ 1627
Davies VJ / 2007 / Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function / Hum Mol
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