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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 5 (5page)
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Background: The Korean native pig (KNP) is generally thought to have come from northern China to the Koreanpeninsula approximately 2000 years ago. KNP pigs were at the brink of extinction in the 1980s, since then effortshave been made to restore the breed by bringing together the remaining stocks in South Korea. As a result, KNPwas registered as a breed in 2006. To find additional breed-specific markers that are distinct among pig breeds,variations in O-linked N-acetylglucosamine transferase (OGT) were investigated. OGT is located on chromosome X andcatalyzes the post-translational addition of a single O-linked-β-N-acetylglucosamine to target proteins.
Findings: Length polymorphism in the intron 20 of OGT was identified. The intron 20 of OGT from Duroc, Landrace,and Yorkshire breeds was 281-bp longer than that from either KNP or Chinese Meishan pigs. The differencebetween the Western pig breeds (BB genotype) and KNP or Meishan pigs (AA genotype) was due to an inserted276-bp element and the 5-bp ACTTG.
Conclusions: The polymorphism in OGT identified in this study may be used as an additional marker fordetermining the breed of origin among Meishan and the Western pig breeds. The length polymorphism suggeststhat the locus near OGT is not fixed in KNP. This marker would be relevant in determining the breed of origin incrossbred pigs between KNP pigs with known genotypes and the Western pig breeds with BB genotypes, thusconfirming the contribution of the X chromosome from each breed.
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참고문헌 (13)
참고문헌 신청
Butkinaree C / 1800 / O-linked beta-N-acetylglucosamine(O-GlcNAc) : Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients
E.H. Kim / 2007 / Detection of Mendelian and Parent-of-origin Quantitative Trait Loci in a Cross between Korean Native Pig and Landrace I. Growth and Body Composition Traits
Ford JJ / 2001 / Interrelationships of porcine X and Y chromosomes with pituitary gonadotropins and testicular size / Biol Reprod 65 : 906 ~ 912
Hanover JA / 1800 / The hexosamine signaling pathway : O-GlcNAc cycling in feast or famine / Biochim Biophys Acta 2010 : 80 ~ 95
Kim JG / 2006 / Molecular cloning of porcine OGT cDNA and mapping to the X chromosome / Biol Reprod (Supplement) : 154 ~
E.H. Kim / 2007 / Detection of Mendelian and Parent-of-origin Quantitative Trait Loci in a Cross between Korean Native Pig and Landrace I. Growth and Body Composition Traits
Ford JJ / 2001 / Interrelationships of porcine X and Y chromosomes with pituitary gonadotropins and testicular size / Biol Reprod 65 : 906 ~ 912
Hanover JA / 1800 / The hexosamine signaling pathway : O-GlcNAc cycling in feast or famine / Biochim Biophys Acta 2010 : 80 ~ 95
Kim JG / 2006 / Molecular cloning of porcine OGT cDNA and mapping to the X chromosome / Biol Reprod (Supplement) : 154 ~
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