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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1 - 6 (6page)
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The fat mass and obesity associated (FTO) gene plays an important role in the regulation of energy homeostasis, fatdeposition and obesity. For this reason, the FTO gene is a physiological and functional candidate gene for carcassand meat quality traits in beef cattle. The objectives of this study were to identify SNPs in the exonic regions of FTOgene and to evaluate the association of these SNPs with carcass traits in Hanwoo (Korean cattle). In this study, wenewly identified two exonic SNPs in Hanwoo population. The g.125550A > T SNP was located in exon 3 and theg.175675C > T SNP was located in exon 6. Genotyping of the two SNP markers was carried out using PCR-RFLPanalysis in Hanwoo steers to evaluate their association with carcass traits. As a result, g.125550A > T SNP genotypewas significantly associated with effects on marbling score. Animals with the AA and TT homozygous genotypeshad a significantly higher marbling score (p < 0.001) than those with AT heterozygous genotype, and this wassignificant after Bonferroni correction of the significance threshold (p = 0.003). Dominance effect was also observedfor the marbling score (P < 0.05) with higher marbling score of homozygous animals. However, no significantassociations with meat quality traits were observed for the g.175675C > T SNP. Our results suggest that the exonicSNP g.125550A > T in the FTO gene may be used as a DNA marker for the selection of Hanwoo with higher marbling.
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참고문헌 (23)
참고문헌 신청
Andreasen CH / 2008 / Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat cccumaulation / Diabetes 57 : 95 ~ 101
Boylston TD / 1995 / Lipid content and composition of Wagyu and domestic breeds of beef / J Agric Food Chem 43 : 1202 ~ 1207
Cameron PJ / 1994 / Relationship between Japanesebeef marbling standard and intramuscular lipid in the M. longissimusthoracis of Japanese Black and American Wagyu cattle / Me
Casas E / 2000 / Quantitative trait loci affection growth and carcass composition of cattle segregating alternate forms of myostatin / J Anim Sci 78 : 560 ~ 569
Dekkers JC / 2004 / Commercial application of marker- and gene assisted selection in livestock: strategies and lessons / J AnimSci 82 : E313 ~ E328
Boylston TD / 1995 / Lipid content and composition of Wagyu and domestic breeds of beef / J Agric Food Chem 43 : 1202 ~ 1207
Cameron PJ / 1994 / Relationship between Japanesebeef marbling standard and intramuscular lipid in the M. longissimusthoracis of Japanese Black and American Wagyu cattle / Me
Casas E / 2000 / Quantitative trait loci affection growth and carcass composition of cattle segregating alternate forms of myostatin / J Anim Sci 78 : 560 ~ 569
Dekkers JC / 2004 / Commercial application of marker- and gene assisted selection in livestock: strategies and lessons / J AnimSci 82 : E313 ~ E328
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