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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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All organisms are being exposed to harmful factors present in the environmental. The combined action of various factors is a distinguishing feature of modern life. An interaction between two chemicals is considered as synergistic when the effect produced is greater than the sum of the two single responses. The biological effects due to the combined action of ionizing radiation with the other factor are hard to estimate and predict in advance. In the current study, we investigated the synergistic effects between ionizing and HgCl2 using fish hepatoma cells (PLHC-1 cells).
The results showed a dramatic decrease of cell viability after simultaneous treatment of PLHC-1 cells with ionizing radiation and HgCl2. Neiither of the two had any cytotoxic effect when treated alone. The cytotoxicity of ionizing radiation was enhanced in the presence of HgCl2. The synergistic effects were observed after exposure of the PLHC-1 cells to ionizing radiation combined with HgCl2. The synergistic interaction was due to an increase of irreversibly damaged cells after the combined exposure. Analysis of the extent of synergistic interaction enables to make quantitative estimation of irreversibly damaged cells after the combined exposure. The present study suggests that PLHC-1 cells can serve as rapid screening tools for detecting the toxicity of harmful factors.
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참고문헌 (21)
참고문헌 신청
Ames BN / 1983 / Dietary carcinogens and anticarcinogens-oxygen radicals and degenerative diseases / Science 221 : 1256 ~ 1264
Bruschweiler BJ / 1995 / Cytotoxicity in vitro of organotin compounds to fish hepatoma cells PLHC-1 (Poecilopsis lucida) / Aquat. Toxicol. 2 : 143 ~ 160
Emanelli T / 1996 / Effect of mercuric chloride intoxication and dimercaprol treatment on deltaaminolevulinate dehydratase from brain, liver and kidney of adult mice / Pharmc
Fent K / 1996 / Ecotoxicology of organotin compounds / Crit. Rev. Toxicol. 26 : 1 ~ 117
Hutchinson F / 1985 / Chemical changes induced in DNA by ionizing radiation / Prog. Nucleic Acid Res. Mol. Biol. 32 : 115 ~ 154
Bruschweiler BJ / 1995 / Cytotoxicity in vitro of organotin compounds to fish hepatoma cells PLHC-1 (Poecilopsis lucida) / Aquat. Toxicol. 2 : 143 ~ 160
Emanelli T / 1996 / Effect of mercuric chloride intoxication and dimercaprol treatment on deltaaminolevulinate dehydratase from brain, liver and kidney of adult mice / Pharmc
Fent K / 1996 / Ecotoxicology of organotin compounds / Crit. Rev. Toxicol. 26 : 1 ~ 117
Hutchinson F / 1985 / Chemical changes induced in DNA by ionizing radiation / Prog. Nucleic Acid Res. Mol. Biol. 32 : 115 ~ 154
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