지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In this study, gametotoxicity and embryotoxicity experiments using Hemicentrotuspulcherrimus were carried out to investigate the ecotoxicological effects of bisphenol A (BPA). Weexamined the effects of BPA on fertilization and normal embryogenesis at various concentrations(0, 300, 500, 800, 1000, and 1500 ppb). The results demonstrated that the fertilization rates werenot changed. The normal embryogenesis rates were gradually decreased in a dose-dependentmanner, and were significantly lowered following 800 ppb BPA treatment (EC50=1056.1 ppb, 95%Cl=981.8~1163.9 ppb). The observed effective concentration and the lowest observed effectiveconcentration of the normal embryogenesis rate were 500 ppb and 800 ppb, respectively. Theembryos showed retarded development at each tested concentration, indicating the fact theembryonic development was delayed due to the increasing concentrations of BPA. Furthermore,we examined the expression of glutathione S-transferase (GST) mRNA at various concentrationsof BPA in H. pulcherrimus. Interestingly, it was found that the expression level of GST mRNAwas significantly increased in the experimental group exposed to BPA. Based on these results, wesuggested that BPA at greater than 800 ppb has a toxic effect during the early embryonic stages ofH. pulcherrimus, and GST mRNA may be used as a biomarker for risk assessment of BPA contamination.
목차
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참고문헌 (22)
참고문헌 신청
Agrawal GK / 2002 / A pathogen-induced novel rice (Oryza sativa L.) gene encodes a putative protein homologous to type II glutathione S-transferases / Plant Sci 163 : 1153 ~
Aluru N / 2010 / Bisphenol A in oocyte leads to growth suppression and altered stress performance in juvenile rainbow trout / PLoS One 5 : e10741 ~
Brotons JA / 1995 / Xenoestrogens released from lacquer coatings in food cans. Environ / Health Persp 103 : 608 ~ 612
Davidson EH / 1998 / Specification of cell fate in the sea urchin embryo: Summary and some proposed mechanisms / Development 125 : 3269 ~ 3290
Greenwood PJ. / 1983 / The influence of an oil dispersant chemserve OSE-DH on the viability of sea urchin gametes. Combined effects of temperature, concentration and exposure
Aluru N / 2010 / Bisphenol A in oocyte leads to growth suppression and altered stress performance in juvenile rainbow trout / PLoS One 5 : e10741 ~
Brotons JA / 1995 / Xenoestrogens released from lacquer coatings in food cans. Environ / Health Persp 103 : 608 ~ 612
Davidson EH / 1998 / Specification of cell fate in the sea urchin embryo: Summary and some proposed mechanisms / Development 125 : 3269 ~ 3290
Greenwood PJ. / 1983 / The influence of an oil dispersant chemserve OSE-DH on the viability of sea urchin gametes. Combined effects of temperature, concentration and exposure
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