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논문 기본 정보

자료유형
학술저널
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거트앤리버 발행위원회 Gut and Liver Gut and Liver 제7권 제5호
발행연도
2013.1
수록면
576 - 584 (9page)

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Background/Aims: The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion therapy for hepatocellular carcinoma (HCC). Methods: We divided 13 HCC patients into the following three groups: group A,lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gelatin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes. Results: The mean free cisplatin concentrations were as follows. For group A, the mean was 48.58 μg/mL at 0 minute,7.31 μg/mL at 5 minutes, 5.70 μg/mL at 10 minutes, and 7.15 μg/mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65μg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 μg/mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C. Conclusions:These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver.
#Cisplatin #Attention #Carcinoma #hepatocellular #Drug delivery

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참고문헌 (1)

참고문헌 신청
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