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논문 기본 정보

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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제53권 제4호
발행연도
2012.1
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788 - 793 (6page)

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Purpose: Chronic low back pain is a common clinical problem. As medication, non-steroidal anti-inflammatory drugs are generally used; however, they are sometimes non-effective. Recently, opioids have been used for the treatment of chronic low back pain, and since 2010, transdermal fentanyl has been used to treat chronic non-cancer pain in Japan. The purpose of the current study was to examine the efficacy of transdermal fentanyl in the treatment of chronic low back pain. Materials and Methods: This study included patients (n=62) that suffered from chronic low back pain and were non-responsive to non-steroidal anti-inflammatory drugs. Their conditions consisted of non-specific low back pain, multiple back operations, and specific low back pain awaiting surgery. Patients were given transdermal fentanyl for chronic low back pain. Scores of the visual analogue scale and the Oswestry Disability Index, as well as adverse events were evaluated before and after therapy. Results: Overall, visual analogue scale scores and Oswestry Disability Index scores improved significantly after treatment. Transdermal fentanyl (12.5 to 50 μg/h) was effective in reducing low back pain in 45 of 62 patients; however, it was not effective in 17 patients. Patients who experienced the most improvement were those with specific low back pain awaiting surgery. Adverse events were seen in 40% of patients (constipation, 29%; nausea, 24%; itching, 24%). Conclusion: Transdermal fentanyl significantly improved visual analog scale scores and Oswestry Disability Index scores in 73% of patients, especially those with specific low back pain awaiting surgery; however, it did not decrease pain in 27% of patients, including patients with non-specific low back pain or multiple back operations.
#Transdermal fentanyl #low back pain #efficacy #adverse events

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참고문헌 (1)

참고문헌 신청
Mirza SK / 2007 / Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pain / Spine 32 : 816 ~ 823 | 2. [학술지(정기간행물)] - Ohtori S / 2011 / Surgical versus nonsurgical treatment of selected patients with discogenic low back pain: a small-sized randomized trial / Spine 36 : 347 ~ 354 | 3. [학술지(정기간행물)] - Wolfe MM / 1999 / Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs / N Engl J Med 340 : 1888 ~ 1899 | 4. [학술지(정기간행물)] - McQuay H. / 1999 / Opioids in pain management / Lancet 353 : 2229 ~ 2232 | 5. [학술지(정기간행물)] - McNairy SL / 1984 / Prescription medication dependence and neuropsychologic function / Pain 18 : 169 ~ 177 | 6. [학술지(정기간행물)] - Allan L / 2001 / Randomised crossover trial of transdermal fentanyl and sustained release oral morphine for treating chronic non-cancer pain / BMJ 322 : 1154 ~ 1158 | 7. [학술지(정기간행물)] - Franco ML / 2002 / Usefulness of transdermal fentanyl in the management of nonmalignant chronic pain: a prospective, observational, multicenter study / Pain Clinic 14 : 99 ~ 112 | 8. [학술지(정기간행물)] - Jeal W / 1997 / Transdermal fentanyl. A review of its pharmacological properties and therapeutic efficacy in pain control / Drugs 53 : 109 ~ 138 | 9. [학술지(정기간행물)] - Adams LL / 2004 / Development of a self-report screening instrument for assessing potential opioid medication misuse in chronic pain patients / J Pain Symptom Manage 27 : 440 ~ 459 | 10. [학술지(정기간행물)] - Schnitzer TJ / 2000 / Efficacy of tramadol in treatment of chronic low back pain / J Rheumatol 27 : 772 ~ 778 | 11. [학술지(정기간행물)] - Ruoff GE / 2003 / Protocol CAPSS-112 Study Group. Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study / Clin Ther 25 : 1123 ~ 1141 | 12. [학술지(정기간행물)] - Peloso PM / 2004 / Protocol TRP-CAN-1 Study Group. Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial / J Rheumatol 31 : 2454 ~ 2463 | 13. [학술지(정기간행물)] - Allan L / 2005 / Transdermal fentanyl versus sustained release oral morphine in strong-opioid naïve patients with chronic low back pain / Spine 30 : 2484 ~ 2490 | 14. [학술지(정기간행물)] - Kosinski MR / 2005 / An observational study of health-related quality of life and pain outcomes in chronic low back pain patients treated with fentanyl transdermal system / Curr Med Res Opin 21 : 849 ~ 862 | 15. [학술지(정기간행물)] - Kalso E / 2007 / Predicting long-term response to strong opioids in patients with low back pain: findings from a randomized, controlled trial of transdermal fentanyl and morphine / BMC Med 5 : 39 ~ | 16. [학술지(정기간행물)] - Kalso E / 2004 / Opioids in chronic non-cancer pain: systematic review of efficacy and safety / Pain 112 : 372 ~ 380 | 17. [학술지(정기간행물)] - Martell BA / 2007 / Systematic review: opioid treatment for chronic back pain: prevalence, efficacy, and association with addiction / Ann Intern Med 146 : 116 ~ 127 google schola

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