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논문 기본 정보

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학술저널
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거트앤리버 발행위원회 Gut and Liver Gut and Liver 제6권 제4호
발행연도
2012.1
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501 - 504 (4page)

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Background/Aims: Autoimmune pancreatitis (AIP) is frequently associated with diabetes mellitus (DM). This study evaluated the effect of steroid therapy on the course of DM in AIP. Methods: Glucose tolerance was examined in 69 patients with AIP. DM onset was classified as either a simultaneous onset with AIP or an exacerbation of pre-existing DM. Based on the changes in the HbA1c levels and insulin dose, the responses of DM to steroids were classified as improved, no change, or worsened. Results: Thirty (46%) patients were diagnosed as having DM (simultaneous onset, n=17; pre-existing, n=13). Three months after starting the steroid treatment, the DM improved in 13 (54%) of 24 DM patients. The DM improved in 55%, had no change in 36%, and worsened in 9% of the 11 simultaneous onset DM patients, and it improved in 54%, had no change in 31%, and worsened in 15% of the 13 pre-existing DM patients. At approximately 3 years after starting the steroid treatment, the DM improved in 10 (63%) of 16 patients. The pancreatic exocrine function improved in parallel with the changes in the DM in seven patients. Conclusions: Because approximately 60% of DM associated with AIP is responsive to steroids in the short- and long-terms, marked DM associated with AIP appears to be an indication for steroid therapy.
#Autoimmune pancreatitis #Diabetes mellitus #Steroids

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참고문헌 (1)

참고문헌 신청
Okazaki K / 2009 / Japanese clinical guidelines for autoimmune pancreatitis / Pancreas 38 : 849 ~ 866 | 2. [학술지(정기간행물)] - Kamisawa T / 2010 / Autoimmune pancreatitis and IgG4-related sclerosing disease / Nat Rev Gastroenterol Hepatol 7 : 401 ~ 409 | 3. [학술지(정기간행물)] - Tanaka S / 2000 / Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis / Lancet 356 : 910 ~ 911 | 4. [학술지(정기간행물)] - Kamisawa T / 2003 / Pancreatic endocrine and exocrine function and salivary gland function in autoimmune pancreatitis before and after steroid therapy / Pancreas 27 : 235 ~ 238 | 5. [학술지(정기간행물)] - Ito T / 2007 / Evaluation of pancreatic endocrine and exocrine function in patients with autoimmune pancreatitis / Pancreas 34 : 254 ~ 259 | 6. [학술지(정기간행물)] - Ito T / 2007 / Treatment for autoimmune pancreatitis: consensus on the treatment for patients with autoimmune pancreatitis in Japan / J Gastroenterol 42 (Suppl 18) : 50 ~ 58 | 7. [학술지(정기간행물)] - Nishino T / 2006 / Long-term outcome of autoimmune pancreatitis after oral prednisolone therapy / Intern Med 45 : 497 ~ 501 | 8. [학술지(정기간행물)] - Nishimori I / 2006 / Influence of steroid therapy on the course of diabetes mellitus in patients with autoimmune pancreatitis: findings from a nationwide survey in Japan / Pancreas 32 : 244 ~ 248 | 9. [학술지(정기간행물)] - Frulloni L / 2010 / Exocrine and endocrine pancreatic function in 21 patients suffering from autoimmune pancreatitis before and after steroid treatment / Pancreatology 10 : 129 ~ 133 | 10. [학술지(정기간행물)] - Otsuki M / 2008 / Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis / J Gastroenterol 43 : 403 ~ 408 | 11. [학술지(정기간행물)] - Seino Y / 2010 / Report of the Committee on the classification and diagnostic criteria of diabetes mellitus: the Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus / Diabetol Int 1 : 2 ~ 20 | 12. [학술지(정기간행물)] - Kamisawa T / 2009 / Standard steroid treatment for autoimmune pancreatitis / Gut 58 : 1504 ~ 1507 | 13. [학술지(정기간행물)] - Kamisawa T / 2010 / Japanese consensus guidelines for management of autoimmune pancreatitis: III. treatment and prognosis of AIP / J Gastroenterol 45 : 471 ~ 477 | 14. [학술지(정기간행물)] - Kamisawa T / 2011 / Management strategies for autoimmune pancreatitis / Expert Opin Pharmacother 12 : 2149 ~ 2159 | 15. [학술지(정기간행물)] - Tanaka S / 2001 / Evidence of primary beta-cell destruction by T-cells and beta-cell differentiation from pancreatic ductal cells in diabetes associated with active autoimmune chronic pancreatitis / Diabetes Care 24 : 1661 ~ 1667 google schola

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