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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 178 - 184 (7page)
- DOI
- 10.7841/ksbbj.2019.34.3.178
이용수
초록· 키워드
오류제보하기
Silk sericin is a water-soluble protein, which derived from silkworm Bombyx mori. Recently, several studies have recognized the various biological activities of sericin. However, studies on the structural changes and physiological activities of silk sericin using the gamma irradiation had not been well addressed. In this study, we evaluated the anti-melanogenic effects of gamma-irradiated sericin by using Melan-a cells. First, both sericin without gamma irradiation and gammairradiated sericin treatment at 100 μg/mL significantly decreased melanin content more than 20%, compared to negative control and especially, 25 kGy gamma-irradiated sericin (GIS) decreased melanin content by 40%, compared to negative control. And 25 kGy GIS significantly decreased microphthalmia-associated transcription factor (MITF) and tyrosinase related protein (TRP)-2 protein expression, compared to negative control, which was similar to the expression of arbutin. Also, in the mitogen-activated protein kinase (MAPK) pathway, which is upstream pathway of MITF, 25 kGy GIS decreased the expression of phosphorylated p38. Taken together, GIS showed anti-melanogenic effect in Melan-a cells by inhibition of p38-dependent MITF pathway.
목차
Abstract
1. INTRODUCTION
2. MATERIAL AND METHOD
3. RESULTS AND DISCUSSION
4. CONCLUSION
REFERENCES
참고문헌 (34)
참고문헌 신청
Ebanks, J. P. / 2009 / Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration / Int. J. Mol. Sci 10:4066~4087
Gillbro, J. M. / 2011 / The melanogenesis and mechanisms of skin-lightening agents-existing and new approaches / Int. J. Cosmet. Sci 33:210~221
Lin, J. Y. / 2007 / Melanocyte biology and skin pigmentation / Nature 445:843~850
Park, H. Y. / 2009 / Cellular mechanisms regulating human melanogenesis / Cell Mol. Life Sci 66:1493~1506
Costin, G. E. / 2007 / Human skin pigmentation:melanocyte modulate skin color in response to stress / FASEB J 21:976~994
Gillbro, J. M. / 2011 / The melanogenesis and mechanisms of skin-lightening agents-existing and new approaches / Int. J. Cosmet. Sci 33:210~221
Lin, J. Y. / 2007 / Melanocyte biology and skin pigmentation / Nature 445:843~850
Park, H. Y. / 2009 / Cellular mechanisms regulating human melanogenesis / Cell Mol. Life Sci 66:1493~1506
Costin, G. E. / 2007 / Human skin pigmentation:melanocyte modulate skin color in response to stress / FASEB J 21:976~994
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UCI(KEPA) : I410-ECN-0101-2019-470-001230303