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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제36권 제2호
- 발행연도
- 2019.1
- 수록면
- 148 - 151 (4page)
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The dose of CD34+ cells is known to influence the outcome of allogeneic peripheral blood stem cell (PBSC) and/or T-cell-depleted transplantation. A previous study proposed that 2×106 CD34+ cells/kg is the ideal minimum dose for allogeneic transplantation, although lower doses did not preclude successful therapy. In the case we present here, CD34+ cells were collected from a matched sibling donor on the day of allogeneic hematopoietic stem cell transplantation; however, the number of cells was not sufficient for transplantation. Consequently, PBSCs were collected three additional times and were infused along with cord blood cells from the donor that were cryopreserved at birth. The cumulative dose of total nuclear cells and CD34+ cells was 15.9×108 cells/kg and 0.95×106 cells/kg, respectively. White blood cells from this patient were engrafted on day 12. In summary, we report successful engraftment after infusion of multiple low doses of CD34+ cells in a patient with severe aplastic anemia.
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참고문헌 (15)
참고문헌 신청
Peinemann F / 2009 / Unrelated donor stem cell transplantation in acquired severe aplastic anemia: a systematic review / Haematologica 94:1732~1742
Copelan EA / 2006 / Hematopoietic stem-cell transplantation / N Engl J Med 354:1813~1826
Bacigalupo A / 1994 / Guidelines for the treatment of severe aplastic anemia. Working Party on Severe Aplastic Anemia (WPSAA) of the European Group of Bone Marrow Transplantation (EBMT) / Haematologica 79:438~444
Young NS / 1995 / The treatment of severe acquired aplastic anemia / Blood 85:3367~3377
Charbonnier A / 1997 / Immune reconstitution after blood cell transplantation / Hematol Cell Ther 39:261~264
Copelan EA / 2006 / Hematopoietic stem-cell transplantation / N Engl J Med 354:1813~1826
Bacigalupo A / 1994 / Guidelines for the treatment of severe aplastic anemia. Working Party on Severe Aplastic Anemia (WPSAA) of the European Group of Bone Marrow Transplantation (EBMT) / Haematologica 79:438~444
Young NS / 1995 / The treatment of severe acquired aplastic anemia / Blood 85:3367~3377
Charbonnier A / 1997 / Immune reconstitution after blood cell transplantation / Hematol Cell Ther 39:261~264
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