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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 35 - 41 (7page)
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Cellular senescence, a permanent state of cell cycle arrest, is believed to have originally evolved to limit the proliferation of old or damaged cells. However, it has been recently shown that cellular senescence is a physiological and pathological program contributing to embryogenesis, immune response, and wound repair, as well as aging and age-related diseases. Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. Thus, cellular senescence has also been considered suppressive mechanism of tumorigenesis. Current studies have revealed that therapy-induced senescence (TIS), a type of senescence caused by traditional cancer therapy, could play a critical role in cancer treatment. In this review, we outline the key features and the molecular pathways of cellular senescence. Better understanding of cellular senescence will provide insights into the development of powerful strategies to control cellular senescence for therapeutic benefit. Lastly, we discuss existing strategies for the induction of cancer cell senescence to improve efficacy of anticancer therapy.
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참고문헌 (86)
참고문헌 신청
Hayflick L / 1965 / The limited in vitro lifetime of human diploid cell strains / Exp Cell Res 37:614~636
Campisi J / 2013 / Aging, cellular senescence, and cancer / Annu Rev Physiol 75:685~705
Deng Y / 2007 / Role of telomeres and telomerase in genomic instability, senescence and cancer / Lab Invest 87:1071~1076
Munoz-Espin D / 2013 / Programmed cell senescence during mammalian embryonic development / Cell 155:1104~1118
Storer M / 2013 / Senescence is a developmental mechanism that contributes to embryonic growth and patterning / Cell 155:1119~1130
Campisi J / 2013 / Aging, cellular senescence, and cancer / Annu Rev Physiol 75:685~705
Deng Y / 2007 / Role of telomeres and telomerase in genomic instability, senescence and cancer / Lab Invest 87:1071~1076
Munoz-Espin D / 2013 / Programmed cell senescence during mammalian embryonic development / Cell 155:1104~1118
Storer M / 2013 / Senescence is a developmental mechanism that contributes to embryonic growth and patterning / Cell 155:1119~1130
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