지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 555 - 558 (4page)
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초록· 키워드
오류제보하기
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disorder with an incidence of approximately 1 in 5,000 to 10,000 live births. TSC has various clinical manifestations such as multiple hamartomas in systemic organs, including the skin. Angiofibromas are the most common skin lesions in patients with TSC. Although benign, angiofibromas develop in childhood and puberty, and can be psychosocially disfiguring for patients. Skin lesions in TSC, specifically angiofibromas, have no significant risk of malignant transformation after puberty; thus, they require no treatment if not prominent. However, the presentation of TSC is important owing to its impact on patient cosmesis. Surgical treatment and laser therapy are the mainstream treatments for angiofibromas. Although the evidence is limited, topical mammalian target of rapamycin inhibitors such as sirolimus (rapamycin) are effective in facial angiofibroma treatment. We describe an adult patient with an angiofibroma who had an excellent response to treatment with topical rapamycin after a single session of carbon dioxide (CO2) laser ablation. The patient showed no sign of relapse or recurring lesions for a year. CO2 laser ablation may serve as a new paradigm of treatment for angiofibromas in TSC. Since the selection of laser devices can be limited for some institutions, we suggest a rather basic but highly effective approach for angiofibroma treatment that can be generally applied with the classic CO2 device.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Schwartz RA / 2007 / Tuberous sclerosis complex : advances in diagnosis, genetics, and management / J Am Acad Dermatol 57:189~202
Jóźwiak S / 1998 / Skin lesions in children with tuberous sclerosis complex : their prevalence, natural course, and diagnostic significance / Int J Dermatol 37:911~917
Staley BA / 2011 / Tuberous sclerosis complex : diagnostic challenges, presenting symptoms, and commonly missed signs / Pediatrics 127:e117
Bittencourt RC / 2001 / Treatment of angiofibromas with a scanning carbon dioxide laser : a clinicopathologic study with longterm follow-up / J Am Acad Dermatol 45:731~735
Fioramonti P / 2014 / Co2/Erbium : YAG/Dye laser combination : an effective and successful treatment for angiofibromas in tuberous sclerosis / Aesthetic Plast Surg 38:192~198
Jóźwiak S / 1998 / Skin lesions in children with tuberous sclerosis complex : their prevalence, natural course, and diagnostic significance / Int J Dermatol 37:911~917
Staley BA / 2011 / Tuberous sclerosis complex : diagnostic challenges, presenting symptoms, and commonly missed signs / Pediatrics 127:e117
Bittencourt RC / 2001 / Treatment of angiofibromas with a scanning carbon dioxide laser : a clinicopathologic study with longterm follow-up / J Am Acad Dermatol 45:731~735
Fioramonti P / 2014 / Co2/Erbium : YAG/Dye laser combination : an effective and successful treatment for angiofibromas in tuberous sclerosis / Aesthetic Plast Surg 38:192~198
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